摘要
Objective:To explore the mechanism of Zhenwu Tang in the treatment of diabetic nephropathy based on network pharmacology.Method:Appling TCMSP database to get the activity of traditional Chinese medicine(TCM)in chemical composition of Zhenwu Tang,and get the target,using of Genecards,OMIM,TTD databases to get the disease related target for diabetic nephropathy,providing database using cytoscape3.7.2 construction of TCM-chemical-disease target network diagram,using the String database to get the corresponding target constructing PPI network,DAVID database is used to obtain the corresponding target GO enrichment analysis and KEGG pathway analysis.Results:Get Zhenwu Tang in active ingredients mainly for beta sitosterol,kaempferol,Stigmasterol,hederagenin,3 beta acetoxyatractylone,core targets including TNF,AKT1 and IL6,involved in biological process(BP)including drug reaction,estradiol,lipopolysaccharide,etc.,It is involved in membrane raft,cave-like depression of cell membrane,plasma membrane,extracellular space and other cellular components(CC),and participates in molecular functions(MF)such as enzyme binding,protein homologous dimerization,heme binding,REDOX enzyme activity,etc.,mainly involving Hepatitis B,TNF signaling pathway,pathway in cancer,etc.Conclusion:This study explored the mechanism of Zhenwu Tang in the treatment of diabetic nephropathy with the method of network pharmacology,providing a theoretical basis for further study of the mechanism of Zhenwu Tang in the treatment of diabetic nephropathy.
基金
TCM Science and Technology Development Project of Shandong Province(No.2019-0043)。
