摘要
目的建立本院区医务人员特异性促甲状腺激素(TSH)参考范围。方法随机纳入2019年7-12月在南昌大学第一附属医院医务工作者健康体检者数据,根据排除标准,共录入1045名体检者,采用化学发光免疫分析法测定血清TSH、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)水平,建立医务人员特异性的TSH正常参考范围。结果所测得TSH值呈非正态分布,本研究建立的新参考范围为0.72~5.46 mIU/L,高于现在本实验室所使用的参考范围。女性血清TSH参考范围为0.70~5.20 mIU/L,男性为0.73~5.60 mIU/L;≤29岁人群中,女性与男性TSH参考范围比较,差异有统计学意义(P<0.05);≥60岁男性TSH参考范围与其他年龄层比较,差异均有统计学意义(P<0.05);≥50岁女性TSH参考范围与其他年龄层比较,差异均有统计学意义(P<0.05)。结论本研究建立本院区健康医务人员TSH的参考区间,为临床医务人员提供准确的实验室数据,以诊断和治疗甲状腺疾病。
Objective To establish the specific thyroid stimulating hormone(TSH)reference range for medical staff in our hospital district.Methods Data from physical check-up of medical staff organized at the First Affiliated Hospital of Nanchang University from July to December 2019 were randomly included.A total of 1045 check-up staff were entered according to exclusion criteria,of whom the serum thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)levels were measured by using chemiluminescence immunoassay to establish a normal reference range for specific TSH of medical staff.Results The measured TSH values were non-normally distributed,and the new reference range established in this study was 0.72-5.46 mIU/L,which was higher than the reference range currently used in our laboratory.The reference range of serum TSH was 0.70-5.20 mIU/L in women and 0.73-5.60 mIU/L in men;The difference between the reference range of TSH in women and men was statistically significant(P<0.05)in the population≤29 years old;The reference range of TSH in men≥60 years old was statistically significant(P<0.05)compared with other age classes,while the reference range of TSH in women≥50 years old was statistically significant(P<0.05)compared with other age classes.Conclusion This study establishes a reference range for thyroid stimulating hormone(TSH)among healthy medical staff in our hospital district and provides clinical medical staff with accurate laboratory data to diagnose and treat thyroid disorders.
作者
刘少正
张青
张庆
叶斌华
LIU Shaozheng;ZHANG Qing;ZHANG Qing;YE Binhua(Department of Nuclear Medicine,the First Affiliated Hospital of Nanchang University,Jiangxi,Nanchang 330006,China)
出处
《中国医药科学》
2021年第17期213-215,230,共4页
China Medicine And Pharmacy
关键词
化学发光
医务人员
甲状腺激素
参考范围
Chemiluminescence
Medical staff
Thyroid hormone
Reference ra nge
