摘要
目的:观察桂香温经止痛颗粒联合中药灌肠对卵巢子宫内膜异位囊肿的疗效,探讨“伏寒伤肾,致瘀损络”的机理以及对疾病的预防。方法:66例患者随机分成两组,治疗组口服桂香温经止痛颗粒结合中药灌肠“红1号”,对照组口服孕三烯酮片,连续治疗3个月经周期,对比治疗前后巧囊最大直径,血液流变学(血浆黏度、红细胞压积、全血黏度)、中医证候,痛经程度。结果:4例病患未规律用药,本研究最终纳入患者62例,经过周期治疗,两组患者较治疗前差异均具有统计学意义(P<0.05)。治疗后,两组患者进行组内对比,其VAS评分、血液流变学等指标比较,差异具有统计学意义(P<0.05),两组均能缓解症状。治疗后两组患者组间对比VAS评分、血液流变学指标,差异具有统计学意义(P<0.05),说明治疗组在止痛、降低血液黏度等方面强于对照组,但在缩小卵巢囊肿方面,两者比较无意义。治疗组缓解疼痛症状,总有效率90.6%(29/32)(P<0.05),痊愈3例,显效20例,有效6例,无效3例。对照组总有效率为80%(24/30)(P<0.05),0痊愈,显效12例,有效12例,无效6例。经统计学分析,差异均具有统计学意义(P<0.05)。结论:桂香温经止痛颗粒联合中药灌肠治疗寒凝血瘀型卵巢子宫内膜异位囊肿,可以有效缩小巧囊最大直径,并改善伴随中医症状,缓解痛经症状,降低血液黏度。
Objective:To observe the curative effect of Guixiang Wenjing Zhitong Granule combined with enema of Chinese medicinal in the treatment of ovarian endometriosis cyst,and to explore the mechanism of‘latent cold damage Kindey,causing blood stasis and collateral injury’and its role in the prevention of the disease.Methods:66 patients were randomly divided into the treatment group and the control group.The treatment group was treated with Guixiang Wenjing Zhitong Granule combined with enema of Chinese medicinal of Hong 1,whereas the control group was treated with Gestrinone Tablet.After three consecutive menstrual cycles,the maximum diameter of ovarian chocolate cyst,hemorheology(plasma viscosity,hematocrit,whole blood viscosity),TCM syndrome and degree of dysmenorrhea were compared before and after the treatment in the two groups.Results:In this study,4 patients did not use drugs regularly,and 62 patients were included finally.After periodic treatment,the differences between the two groups were statistically significant(P<0.05).VAS score and hemorheology indicators were significantly improved after the treatment compared to those before the treatment in the two groups(P<0.05);of which there were statistical differences between the two groups after the treatment(P<0.05),indicating that the treatment group was better than the control group in pain relief and reducing blood viscosity,but there was no statistical difference in reducing ovarian cyst between the two groups.In terms of relieving pain,the total effective rate was 90.6%(29/32)in the treatment group,with 3 cured cases,20 markedly effective cases,6 effective cases and 3 invalid cases;the total effective rate was 80%(24/30)in the control group,with 0 cured cases,12 markedly effective cases,12 effective cases and 6 invalid cases;the differences between the two groups were statistically significant(P<0.05).Conclusion:Guixiang Wenjing Zhitong Granule combined with enema of Chinese medicinal can effectively reduce the maximum diameter of ovarian endometriosis cy
作者
宋雯
吴丹
丛慧芳
吕顺
SONG Wen;WU Dan;CONG Huifang;LYU Shun(Heilongjiang University of Chinese Medicine, Harbin 150040, China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China;Affiliated Hospital of Chengdu University, Chengdu 610000, China)
出处
《中医药学报》
CAS
2021年第10期72-75,共4页
Acta Chinese Medicine and Pharmacology
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015061)
黑龙江省卫生计生委科研课题(2016-553)
黑龙江省自然科学基金面上项目(H2015025)。
关键词
卵巢子宫内膜异位囊肿
寒凝血瘀型
桂香温经止痛颗粒
中药直肠滴入
Ovarian endometriosis cyst
Pattern of cold congealing and blood stasis
Guixiang Wenjing Zhitong Granule
Enema of Chinese medicinal
