摘要
目的探讨帕金森病患者伴发抑郁的危险因素,分析影响帕金森病患者生活质量的主要因素。方法纳入2018年6月至2020年5月在该院就诊的125例帕金森病患者。收集患者基本信息,采用相关量表评估患者运动及非运动症状。根据HAMD评分≥8分和<8分将患者分为抑郁组(89例)和非抑郁组(36例)。分析伴发抑郁的危险因素以及生活质量的主要影响因素。结果单因素分析显示两组之间病程(z=-3.047)、等效剂量(z=-2.205)、UPDRSⅢ评分(z=-4.220)、H-Y分级(χ^(2)=6.053)、SCOPA-AUT评分(z=-3.968)、MMSE评分(z=-3.359)、MoCA评分(z=-2.910)、PSQI评分(t=-3.985)、是否伴有EDS(χ^(2)=9.089)、FS-14评分(z=-4.972)和KPPS评分(z=-2.949)比较,差异具有统计学意义(P<0.05)。多因素分析显示病程、SCOPA-AUT、MMSE和FS-14评分是抑郁的危险因素(P<0.05)。H-Y分级、UPDRSⅢ、SCOPA-AUT、MoCA和FS-14评分是生活质量的主要影响因素(P<0.05)。结论病程、自主神经功能障碍、认知功能障碍和疲劳是帕金森病伴发抑郁的主要危险因素。运动症状、病情严重程度、自主神经功能障碍、认知功能障碍和疲劳是影响帕金森病患者生活质量的主要因素。
Objective To investigatethe risk factors for depression and the influencing factors for quality of life in pa⁃tients with Parkinson’s disease.Methods A total of 125 patients with Parkinson’s disease who attended our hospital from June 2018 to May 2020 were enrolled.Basic information was collected and related scales were used to assess motor and non-motor symptoms.According to Hamilton Depression Scale(HAMD)score,the patients were divided into depression group(89 patients with HAMD score≥8)and non-depression group(36 patients with HAMD score<8),and the risk factors for depression and the influencing factors for quality of life were analyzed.Results The univariate analysis showed that there were significant differences between the two groups in course of disease(z=-3.047,P<0.05),equivalent dose(z=-2.205,P<0.05),Unified Parkinson’s Disease Rating Scale III(UPDRSIII)score(z=-4.220,P<0.05),H-Y stage(χ^(2)=6.053,P<0.05),SCOPA-AUT score(z=-3.968,P<0.05),Mini-Mental State Examination(MMSE)score(z=-3.359,P<0.05),Montreal Cognitive Assessment(MoCA)score(z=-2.910,P<0.05),Pittsburgh Sleep Quality Indexscore(t=-3.985,P<0.05),presence or absence ofexcessive daytime sleepiness(χ^(2)=9.089,P<0.05),FS-14 score(z=-4.972,P<0.05),and KPPS score(z=-2.949,P<0.05).The multivariate analysis showed that course of disease,SCOPA-AUT score,MMSE score,and FS-14 score were the risk factors for depression(P<0.05),and H-Y stage,UPDRSIII score,SCOPA-AUT score,MoCA score,and FS-14 score were the main influencing factors for quality of life(P<0.05).Conclusions Course of disease,autonomic dysfunction,cognitive disorder,and fatigue are the main risk factors for depression in Parkinson’s disease,and motor symptoms,disease severity,autonomic dysfunction,cognitive disorder,and fatigue are the main influ⁃encing factors forquality of life inpatients with Parkinson’s disease.
作者
景何灵
蒋家美
JING He-Ling;JIANG Jia-Mei(The Third Peoples Hospital of Panzhihua,Panzhihua,Sichuan 617000,China)
出处
《国际神经病学神经外科学杂志》
2021年第4期327-332,共6页
Journal of International Neurology and Neurosurgery
关键词
帕金森病
抑郁
危险因素
生活质量
Parkinson’s disease
depression
risk factor
quality of life
