摘要
目的探讨限制性液体管理治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者临床效果。方法选取2019年1月至2020年12月上海市东方医院吉安医院收治的120例COPD合并Ⅱ型呼吸衰竭患者作为研究对象,按照随机数表法分为观察组和对照组,每组各60例。两组均使用常规治疗,对照组在常规治疗基础上给予非限制性液体管理,观察组在常规治疗基础上给予限制性液体管理,比较治疗1周内两组通气时间、补液量。比较治疗前和治疗1周后两组血气指标[二氧化碳分压(PaCO_(2))、血氧分压(PaO_(2))、血氧饱和度(SpO_(2))、pH]、血液指标[乳酸(LA)、N末端B型利钠肽原(NT-proBNP)]。结果观察组治疗1周内的通气时间、补液量低于对照组,差异有统计学意义(P<0.05)。观察组治疗1周后的LA、NT-proBNP、PaCO_(2)均低于对照组,差异有统计学意义(P<0.05);观察组治疗1周后的pH、PaO_(2)、SpO_(2)高于对照组,差异有统计学意义(P<0.05)。结论限制性液体管理用于COPD合并Ⅱ型呼吸衰竭患者有利于恢复其正常血气水平,缩短通气时间。
Objective To study the clinical effect of restrictive fluid management in the treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with typeⅡrespiratory failure.Methods Totally 120 patients with COPD complicated with typeⅡrespiratory failure admitted to Ji′an Hospital of Shanghai East Hospital from January 2019 to December 2020 were selected as the study subjects,and they were divided into observation group and control group according to the random number table method,with 60 cases in each group.The two groups were given conventional treatment,and patients in control group were given non-restrictive fluid management on the basis of conventional treatment,and patients in observation group were given restrictive fluid management on the basis of conventional treatment.The ventilation time and fluid replacement volume of the two groups were compared within 1 week of treatment.The blood gas indexes(partial pressure of carbon dioxide[PaCO_(2)],arterial oxygen pressure[PaO_(2)],blood oxygen saturation[SpO_(2)],pH)and blood indexes(lactic acid[LA],N-terminal B-type natriuretic peptide[NT-proBNP])were compared between the two groups before treatment and after 1 week of treatment.Results Within 1 week of treatment,the ventilation time and fluid replacement volume in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the LA,NT-proBNP and PaCO_(2)of observation group were lower than those of control group,the differences were statistically significant(P<0.05).The pH value,PaO_(2)and SpO_(2)of observation group after 1 week of treatment were higher than those of control group,the differences were statistically significant(P<0.05).Conclusion Restrictive fluid management for patients with COPD complicated with typeⅡrespiratory failure is beneficial to restore the normal blood gas levels and shorten the ventilation time.
作者
刘婷
徐小妹
张文
袁国庆
LIU Ting;XU Xiao-mei;ZHANG Wen;YUAN Guo-qing(Intensive Care Unit,Ji′an Hospital of Shanghai East Hospital,Jiangxi Province,Ji′an343000,China)
出处
《中国当代医药》
CAS
2021年第28期57-60,共4页
China Modern Medicine
基金
江西省吉安市科技计划任务(医疗卫生107)。
关键词
限制性液体管理
慢性阻塞性肺疾病
呼吸衰竭
通气时间
血气指标
Restrictive fluid management
Chronic obstructive pulmonary disease
Respiratory failure
Ventilation time
Blood gas indexes
