摘要
目的探讨PUMA、IQGAP1蛋白在胰腺癌中的表达及与临床病理、预后生存的相关性。方法选取2016年10月至2018年10月本院收治的胰腺癌患者胰腺癌组织标本、远离胰腺肿瘤3 cm的癌旁组织标本各74份,比较两组织中PUMA、IQGAP1蛋白的表达情况,并探讨其与病理特征的关系。随访2年,了解74例患者生存率,采用ROC曲线分析不同PUMA、IQGAP1表达的胰腺癌患者预后2年生存情况,采用Logistic回归模型分析影响胰腺癌患者2年预后的独立危险因素。结果胰腺癌组织中的PUMA阳性率显著低于癌旁组织,IQGAPl阳性率显著高于癌旁组织,差异均有统计学意义(P<0.05)。TNM分期为Ⅲ~Ⅵ期、有淋巴结转移、分化程度为中-低分化的胰腺癌患者PUMA阴性率、IQGAPl阳性率更高(P<0.05)。74例胰腺癌患者2年生存率为16.22%。PUMA阴性表达、IQGAPl阳性表达的胰腺癌患者死亡率高于PUMA阳性表达、IQGAPl阴性表达的患者,差异有统计学意义(P<0.05)。生存分析显示PUMA(表达阳性)、IQGAPl(表达阴性)者生存期较长,Keplan-meier生存曲线明显不同(P<0.05)。TNM(Ⅲ~Ⅵ期)、淋巴结转移(有)、分化程度(中-低分化)、PUMA(表达阴性)、IQGAPl(表达阳性)为影响胰腺癌患者预后生存的独立危险因素(P<0.05)。结论 PUMA阴性、IQGAPl阳性为影响胰腺癌患者预后生存的危险因素,临床可通过加强监测二者表达情况,以评估胰腺癌患者病情进展情况及预后。
Objective To investigate the expression of PUMA and IQGAP1 in pancreatic cancer and their correlation with clinicopathology and prognostic survival.Methods From October 2016 to October 2018,74 samples of pancreatic cancer tissue specimens and paracancerous tissue specimens 3 cm away from the pancreatic tumor were selected from the patients with pancreatic cancer admitted to our hospital from October 2016 to October 2018.The expressions of PUMA and IQGAP1 in two tissues were compared.Its relationship with pathological characteristics was explored,74 patients were followed up for 2 years to understand the 2-year survival rate of patients.The ROC curve was used to analyze the 2-year prognosis of patients with different PUMA and IQGAP1 expressions,and the logistic regression model was used to analyze the independent risk factors affecting the 2-year prognosis of patients with pancreatic cancer.Results The positive rate of PUMA in pancreatic cancer tissue was significantly lower than that in normal tissues adjacent to cancer,and the positive rate of IQGAP1 was significantly higher than that in normal tissues adjacent to cancer.The differences were statistically significant(P<0.05).In patients with TNM stage Ⅲ-Ⅵ,lymph node metastasis,and moderate-poor differentiation,the negative rate of PUMA was higher than the positive rate of PUMA,and positive rate of IQGAP1 was higher than the negative rate of IQGAP1,and the difference was statistically significant(P<0.05).In the 74 patients with pancreatic cancer,the 2-year survival rate was 16.22%.The mortality of patients with pancreatic cancer and negative expression of PUMA and positive expression of IQGAP1 was higher than that of patients with positive expression of PUMA and negative expression of IQGAP1,the difference was statistically significant(P<0.05).Survival analysis showed that PUMA(positive expression) and IQGAP1(negative expression) had longer survival times,and Keplan-meier survival curves were significantly different(P<0.05).TNM(stage Ⅲ~Ⅵ),lymph node metas
作者
胡怀远
夏燕
雍翔
邹萍
刘岩
HU Huaiyuan;XIA Yan;YONG Xiang;ZOU Ping;LIU Yan(Department of Pathology,General Hospital of Wanbei Coal Power Group,Suzhou,Anhui,China,234011)
出处
《分子诊断与治疗杂志》
2021年第9期1515-1519,共5页
Journal of Molecular Diagnostics and Therapy
基金
蚌埠医学院课题(BYKY17190)。
