摘要
骨髓间充质干细胞(BMSCs)是骨髓内的非造血干细胞,具有多向分化、低免疫源性等优势。肝移植是目前终末期肝病的有效治疗方法,但因肝源短缺及免疫排斥等缺陷,其临床运用严重受限。BMSCs经过不同的诱导方法可以在体外分化为肝细胞,应用于晚期肝病的治疗,是目前治疗肝损伤的一种新兴治疗手段。本文主要将近年来BMSCs的分离培养及鉴定方案、诱导BMSCs向肝细胞分化的常用方法及分化机制进行综述,以期为今后临床运用BMSCs治疗终末期肝病提供更加充分的理论依据。
Bone marrow mesenchymal stem cells(BMSCs)are non-hematopoietic stem cells in the bone marrow that have the advantages of multidirectional differentiation and low immunogenicity.Although liver transplantation is an effective treatment for end-stage liver disease,its clinical application is severely limited by the shortage of donor liver sources and rate of immune rejection.The differentiation of BMSCs into hepatocytes in vitro using different induction method is applied in the treatment of advanced liver disease,and represents a new treatment method for liver injury.This article summarizes the isolation culture,and the common method and mechanisms for inducing BMSC differentiation into hepatocytes that have been described in the literature in recent years.A clear understanding of these processes will provide a strong theoretical basis for future clinical applications of BMSCs in the treatment of end-stage liver disease.
作者
李裕珍
冯丽娟
潘益巧
阮博文
周晓玲
LI Yuzhen;FENG Lijuan;PAN Yiqiao;RUAN Bowen;ZHOU Xiaoling(Guangxi University of Chinese Medicine,Nanning 53000,China;the Third Affiliated Hospital of Guangxi University of Chinese Medicine,Liuzhou 545000)
出处
《中国比较医学杂志》
CAS
北大核心
2021年第9期130-135,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81760855)
柳州市应用技术研究与开放计划项目(2018AF10503)
广西医药大学校级一般硕士研究生科研创新项目(YCSY2020057)。
关键词
骨髓间充质干细胞
诱导分化
肝细胞
终末期肝病
bone marrow mesenchymal stem cells
induced differentiation
hepatocytes
end-stage liver disease
