摘要
目的:制备青葙总皂苷滴丸,并对其进行质量评价。方法:采用单因素和正交试验相结合,以滴丸的圆整度、重量差异、溶散时限为评价指标,对混合基质比例、药物与基质的用量比例、料液温度、滴速等因素进行优选,确定制备滴丸的最佳工艺;采用紫外-可见分光光度法对青葙总皂苷滴丸中青葙总皂苷进行定量研究。结果:最佳制备工艺为:PEG4000∶PEG6000(2∶1),药物∶基质(1∶5),料液温度为80℃,滴速为40滴/min。结论:优选的青葙总皂苷滴丸制备方法稳定、可行,质量标准能够评价青葙总皂苷的含量,且方法简便、易行,结果稳定、可靠。
Objective:To prepare the dropping pills of total saponins in Celosia argentea and to evaluate its quality.Methods:The appearance roundness,weight variation and resolving time of dropping pills were used as evaluation indicators to optimize the preparation conditions by single-factor and orthogonal experiments.The effects of mixture-matrix ratio,drug-matrix ratio,feed temperature and dropping speed on the preparation of dropping pills were investigated.UV-Vis spectrophotometry was used to determine the content of total saponins in dropping pills of Celosia argentea.Results:The optimal preparation condition was as follows:PEG4000 and PEG6000 ratio of 2:1,drug-matrix ratio of 1:5,material temperature at 80℃,dropping speed of 40 drops/min.Conclusion:The optimized preparation of dropping pills of Celosia argentea were stable and feasible.The determination of total saponins was simple,and the results were stable and reliable.
作者
邾枝花
王船英
周月乔
黄平
ZHU Zhi-hua;WANG Chuan-ying;ZHOU Yue-qiao;HUANG Ping(Department of Pharmacy,Anhui Medical College,Hefei 230601,China)
出处
《宜春学院学报》
2021年第6期17-20,51,共5页
Journal of Yichun University
基金
安徽省优秀青年人才支持计划项目(项目编号:gxyq2018172)
安徽省质量工程项目(项目编号:2020jxtd134,2020kfkc283)。
关键词
青葙总皂苷
滴丸
制备
质量评价
total saponin in Celosia argentea
dropping pill
preparation
quality evaluation
