摘要
近年来结直肠癌的发病率及病死率呈逐年上升趋势。随着分子生物学研究的深入和驱动基因的发现,结直肠癌的治疗逐渐向个体化、精准化方向发展。人表皮生长因子受体2(HER2)作为表皮生长因子受体家族的第2位成员参与对细胞生长、繁殖、分裂的调控及控制肿瘤的生长。文章就HER2的表达与结直肠癌相关性的研究进展进行综述。
In recent years,the incidence and mortality rates of colorectal cancer are increasing year by year.With the deepening of molecular biology research and the discovery of driver genes,the treatment of colorectal cancer has gradually developed to the direction of individuation and precision.As the second member of the epidermal growth factor receptor family,human epidermal growth factor receptor 2(HER2)is involved in the regulation of cell growth,reproduction and division and the control of tumor growth.This article reviews the correlation between expression of HER2 and colorectal cancer.
作者
倪印
刘彦龙
崔滨滨
Ni Yin;Liu Yanlong;Cui Binbin(Department of Colorectal Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China)
出处
《肿瘤研究与临床》
CAS
2021年第8期633-637,共5页
Cancer Research and Clinic
关键词
结直肠肿瘤
人表皮生长因子受体2
新辅助治疗
靶向治疗
Colorectal neoplasms
Human epidermal growth factor receptor 2
Neoadjuvant therapy
Targeted therapy
