摘要
SLP-2(stomatin-like protein 2)为近年来发现的Stomatin超家族的新成员。研究发现,SLP-2参与多种恶性肿瘤的发生发展,有望成为多种肿瘤早期筛查、靶向治疗以及预后评估的肿瘤标志物。全文从SLP-2结构功能、肿瘤表型、信号通路和临床转化等方面探讨SLP-2在肿瘤领域的研究进展,旨在探讨SLP-2的潜在临床价值。
Stomatin-like protein-2(SLP-2)has been discovered as a new member of the Stomatin superfamily in recent years.Studies have found that SLP-2 is involved in the development and progression of a variety of malignant tumors,which is expected to be a novel diagnostic marker,therapeutic target and prognosis factor for cancers.In this review,the research advances of SLP-2 in tumors are discussed from the aspects of SLP-2 structure and function,roles of SLP-2 in tumor phenotype,SLP-2-related signal pathway,and preliminary translational attempts,aiming to explore its potential clinical application.
作者
李丹茜
蒋涛涛
俞阳
陈昊
LI Dan-qian;JIANG Tao-tao;YU Yang;CHEN Hao(Second Clinical Medical College,Lanzhou University,Lanzhou 730030,China;Lanzhou University Second Hospital,Lanzhou 730030,China;Gansu Provincial Key Laboratory of Digestive System Tumors,Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《肿瘤学杂志》
CAS
2021年第8期667-671,共5页
Journal of Chinese Oncology
基金
兰州大学第二医院“萃英学子科研培育”计划(CYXZ-12)
兰州市城关区科技计划项目(2019RCCX0034)。
关键词
SLP-2
生理功能
信号通路
恶性肿瘤
SLP-2
physiological functions
signal pathway
malignant tumor
