摘要
目的探讨Six1在非小细胞肺癌中的表达及其与临床病理特征的关系。方法选择接受根治性手术治疗的早中期非小细胞肺癌患者127例作为研究对象,取所有患者的癌灶组织标本(病灶组)与癌旁正常肺部组织标本(癌旁组),采用免疫组化法检测Six1表达情况。调查患者的临床病理特征并进行相关性分析。结果病灶组的Six1表达阳性率为73.2%,高于癌旁组的26.0%(P<0.05)。不同淋巴结转移、临床分期、组织学分化、肿瘤最大直径的肺癌患者Six1表达阳性率对比差异有统计学意义(P<0.05)。Pearson相关分析显示肺癌的临床分期、肿瘤最大直径、组织学分化、淋巴结转移与Six1表达阳性率都存在相关性(P<0.05)。所有患者随访到2020年11月1日,生存106例,死亡21例,死亡率为16.5%,平均生存时间为(16.21±4.24)个月。单因素与多因素Cox比例风险模型分析显示Six1表达阳性率都为影响患者预后死亡的独立危险因素(P<0.05)。结论Six1在肺癌中呈现高表达状况,与患者的临床病理特征显著相关,是影响肺癌患者预后的重要危险因素。
Objective To investigate the expression of Six1 in non-small cell lung cancer and its relationship with clinicopathological characteristics.Methods 127 cases of patients with early and mid-stage non-small cell lung cancer who were received radical surgery were selected as the research objects.The cancer tissue specimens from all patients(lesion group)and normal lung tissue samples adjacent to cancer(paracancerous group)were collected,the expression of Six1 were detected by immunohistochemistry.And were to investigate the clinicopathological characteristics of patients and given correlation analysis.Results The positive rate of Six1 expression in the lesion group were 73.2%,which were higher than 26.0%in the adjacent group(P<0.05).The positive rates of Six1 expression in lung cancer patients with different lymph node metastasis,clinical stage,histological differentiation,and maximum tumor diameter were statistically different(P<0.05).Pearson correlation analysis showed that the clinical stage of lung cancer,the maximum tumor diameter,histological differentiation,lymph node metastasis and the positive rate of Six1 expression were all correlated(P<0.05).All patients were followed up to November 1,2020,there were 106 cases were survived,21 cases were died,the mortality rate were 16.5%,and the average survival time were 16.21±4.24 months.Univariate and multivariate Cox proportional hazard model analysis showed that the positive rate of Six1 expression were an independent risk factor affecting the prognosis of death(P<0.05).Conclusion Six1 is highly expressed in lung cancer,which is significantly related to the clinicopathological characteristics of patients and is important risk factor affects the prognosis of lung cancer patients.
作者
王春侠
门翔
郑大炜
段秋立
周小果
董万里
李展
WANG Chunxia;MEN Xiang;ZHENG Dawei(Nanyang Central Hospital,Nanyang,473009)
出处
《实用癌症杂志》
2021年第9期1426-1428,1433,共4页
The Practical Journal of Cancer
基金
河南省科技攻关项目(编号:182102310184)。
关键词
Six1
肺癌
病理特征
相关性
危险因素
Six1
Lung cancer
Pathological characteristics
Correlation
Risk factors
