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呼出气一氧化氮联合肺功能指标对支气管哮喘诊断的临床研究 被引量:4

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摘要 目的通过检测支气管哮喘患者呼出气一氧化氮水平和肺功能指标,来分析其对哮喘患者的诊断及鉴别诊断意义。方法选取本院2019年10月至2020年12月就诊患者,支气管哮喘患者为实验组60例,上呼吸道感染患者为对照组30例。比较实验组和对照组患者的呼出气一氧化氮及肺功能指标,并分析呼出气一氧化氮联合肺功能指标对哮喘的诊断价值。结果观察组的FEV1(L)、PEF%Pre、MEF75%、MEF50%虽然较对照组低,没有统计学意义(P>0.05);观察组的MEF25%、FeNO(PPb)均低于对照组,P<0.05,有统计学意义。部分控制组和完全控制组相比,部分控制组的FEV1(L)、PEF%Pre较对照组偏低,但P>0.05,没有统计学意义;观察组的MEF75%、MEF50%、MEF25%、FeNO(PPb)均低于对照组,有统计学意义P<0.05。Pearson相关分析显示,FeNO与MEF50%、MEF25%有负相关性,与FEV1(L)、PEF%Pre、MEF75%无相关性。ROC曲线显示,呼出气一氧化氮的最佳截断值为46.43 PPb,ROC曲线下面积为0.847,在此截点下诊断灵敏度为69.7%,特异度为94.6%。结论呼出气一氧化氮联合肺功能指标可提高支气管哮喘诊断的正确率,对临床医师有一定的指导意义。
作者 白黎峰
出处 《医药论坛杂志》 2021年第9期115-118,共4页 Journal of Medical Forum
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