摘要
生长是一个连续非线性的过程,不同时期的调控机制及生长特点不尽相同。骨骼的生长受多种因素的影响,而软骨生长板是骨骼生长和发育的关键。包括营养、内分泌激素、炎症细胞因子、旁分泌信号、细胞外基质等在内的多种调控机制通过调节生长板软骨细胞的成熟与分化在骨骼的生长过程中发挥作用。掌握儿童正常生长规律和调控机制对矮身材儿童的诊断、鉴别诊断及此后的规范化治疗具有极其重要的作用。
Growth is a continuous non-linear process,and the regulation mechanism and growth characteristics in different periods are different.The growth of bones is affected by many factors,and the cartilage growth plate is the key to bone growth and development.Various regulatory mechanisms,including nutrition,endocrine hormones,inflammatory cytokines,paracrine signals,extracellular matrix,etc.,play a role in the growth of bones by regulating the maturation and differentiation of growth plate chondrocytes.Mastering the normal growth laws and regulation mechanisms is extremely important for the diagnosis,differential diagnosis,and standardized treatment of children with short stature.
作者
黄轲
傅君芬
HUANG Ke;FU Jun-fen(Department of Endocrinology,the Children’s Hospital of Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310052,China)
出处
《中国实用儿科杂志》
CSCD
北大核心
2021年第8期570-573,共4页
Chinese Journal of Practical Pediatrics
基金
国家自然科学基金(81570759)
十三五国家重点研发计划(2016YFC1305300)
国家卫生计生委科学研究基金-浙江省医药卫生重大科技计划重大项目(WKJ-ZJ-1804)。
关键词
生长
调控机制
儿童
growth
regulation mechanism
child
