摘要
皮肤作为哺乳动物最大器官,是抵御外界刺激的第1道防护屏障。汗腺是皮肤重要附属器之一,在维持电解质平衡和调节体温方面起着重要作用。大面积深度烧伤患者通常损伤会达真皮深层甚至皮肤全层,损伤汗腺修复困难,甚至无法再生,患者排汗和体温调节功能受到严重影响,生活质量降低。如何实现汗腺的功能化成为损伤皮肤再生医学的重要研究内容之一。本文对干细胞、组织工程等汗腺再生修复的转化应用技术进行阐述,拟为汗腺再生研究提供理论参考。
As the largest organ in mammals,skin is the first protective barrier against external stimuli.Sweat glands are one of the important cutaneous appendages and play an important role in maintaining electrolyte balance and regulating body temperature.Patients with extensive deep burns usually suffer from damage to deep dermis or the entire skin layer.The damaged sweat glands are difficult to repair and even unable to regenerate,which seriously affects patients'sweating and thermo-regulation function,reduces patients'quality of lives.How to achieve the functionalization of sweat glands has become one of the important researches in regenerative medicine of damaged skin.This review summarizes the translational and application technology of sweat gland regeneration and repair using stem cells and tissue engineering,in order to provide a theoretical basis for the research of sweat gland regeneration.
作者
曾迎楠
康洋波
许永安
Zeng Yingnan;Kang Yangbo;Xu Yong'an(Department of Emergency Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2021年第9期900-904,共5页
Chinese Journal of Burns
基金
国家自然科学基金面上项目(81571916,81372079)。
关键词
汗腺
转化型研究
间充质干细胞
组织工程
Sweat glands
Translational research
Mesenchymal stem cells
Tissue engineering
