摘要
目的探讨局部亚低温联合氨甲环酸注射液治疗蛛网膜下腔出血(SAH)的效果。方法选取2020年1月至2021年1月于河南科技大学第一附属医院接受治疗的78例SAH患者为研究对象,依据随机数表法将其分为对照组(39例,氨甲环酸)与观察组(39例,氨甲环酸联合局部亚低温),治疗3 d后观察两组临床疗效。对比两组治疗前、治疗3 d后大脑中动脉(MCA)平均血流速度、昏迷情况及炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平,并记录两组并发症发生情况。结果治疗3 d后,观察组临床疗效优于对照组,两组MCA平均血流速度低于治疗前,GCS评分高于治疗前,且观察组MCA平均血流速度[(88.79±12.47)cm·s^(-1)]低于对照组[(97.65±15.32)cm·s^(-1)],GCS评分[(12.86±1.64)分]高于对照组[(10.87±1.73)分],差异有统计学意义(P<0.05)。治疗3 d后,两组hs-CRP、IL-6水平均低于治疗前,且观察组hs-CRP[(16.95±5.74)ng·L^(-1)]、IL-6[(7.96±2.03)ng·L^(-1)]水平低于对照组[(24.86±7.38)、(9.83±2.41)ng·L^(-1)],差异有统计学意义(P<0.05);观察组并发症发生率(7.69%)与对照组(10.26%)比较,差异无统计学意义(P>0.05)。结论局部亚低温联合氨甲环酸注射液治疗可降低SAH患者炎症因子水平,降低MCA平均血流速度,减轻昏迷情况,提高临床效果,且安全性高。
Objective To investigate the effect of local mild hypothermia combined with tranexamic acid injection in treating subarachnoid hemorrhage(SAH).Methods A total of 78 patients with SAH treated in the First Affiliated Hospital of Henan Science and Technology University from January 2020 to January 2021 were selected as the research subjects.They were divided into control group(39 cases,tranexamic acid)and observation group(39 cases,tranexamic acid combined with local mild hypothermia)by a random number table method.After 3 days of treatment,the clinical efficacy of the two groups was observed,and the mean blood flow velocity of middle cerebral artery(MCA),coma condition and level of inflammatory factors[high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)]were compared in both groups before and 3 days after treatment,and the complications of the two groups were recorded.Results After 3 days of treatment,the clinical efficacy of the observation group was higher than control group.Compared with those before treatment,the mean blood flow velocity of MCA in both groups was lower,the GCS score was higher.The mean blood flow velocity of MCA in the observation group[(88.79±12.47)cm·s^(-1)]was lower than that in the control group[(97.65±15.32)cm·s^(-1)],the GCS score[(12.86±1.64)points]was higher than that in the control group[(10.87±1.73)points](P<0.05).After 3 days of treatment,hs-CRP and IL-6 levels in both groups were lower than those before treatment,and the hs-CRP[(16.95±5.74)ng·L^(-1)],IL-6[(7.96±2.03)ng·L^(-1)]in the observation group were lower than those[(24.86±7.38),(9.83±2.41)ng·L^(-1)]in control group(P<0.05).There was no difference in the incidence of complications between observation group(7.69%)and control group(10.26%)(P>0.05).Conclusion Local mild hypothermia combined with tranexamic acid injection can reduce the level of inflammatory factors in patients with SAH,slow down the average blood flow velocity of MCA,reduce coma condition,improve the clinical effect,and has high safety.
作者
邓旻楠
DENG Minnan(Department of Neurblogy,the First Affiliated Hospital of Henan Science and Technology University,Luoyang 471000,China)
出处
《河南医学研究》
CAS
2021年第27期5051-5054,共4页
Henan Medical Research
关键词
蛛网膜下腔出血
氨甲环酸
局部亚低温
炎症因子
subarachnoid hemorrhage
tranexamic acid
local mild hypothermia
inflammatory factor
