摘要
The treatment of cerebral aneurysms(CAs)is of social importance,because poor outcomes result in subarachnoid hemorrhages after rupture.However,there is currently no medical treatment available to prevent the progression and rupture of CAs,which results in a large number of patients without receiving treatment.Recent studies using human samples have revealed the presence of inflammatory responses in lesions and also the possible correlation of inflammation with CA progression or rupture.Furthermore,experimental studies using animal models of CAs have supported the notion from human studies and have clarified the crucial contribution of inflammation to the pathogenesis.In this process,a vicious cycle/positive feedback loop includes the nuclear factor-kappa B(NF-kB)activation,which plays a role in amplifying inflammatory responses to the point of chronicity.In addition,the infiltration of macrophages via NF-kB-mediated monocyte chemotactic protein 1 induction expands inflammation in whole arterial walls and contributes to the degeneration of media by producing various cytokines and tissue-destructive proteases.These series of studies have provided an important insight-antiinflammatory drugs can be therapeutically significant in the treatment of CAs.Indeed,in animal models,some drugs with an antiinflammatory effect effectively suppressed CA formation and progression,which supports this hypothesis.In addition,in human cases,some case-control studies have reported the preventive effect of statins and nonsteroidal antiinflammatory drugs on CA rupture.Therefore,the development of novel medical treatment for preventing the progression and rupture of CAs is needed in the near future.In this literature review,articles were selected by performing a PubMed search using the key words“cerebral aneurysm”and“inflammation”.
