摘要
目的对静脉药物集中调配中心(PIVAS)抗肿瘤药物不合理医嘱进行分析及有效干预后效果评价,以期进一步规范临床抗肿瘤药物的合理使用。方法对2018年1—6月PIVAS经药师审方并建议修改的不合理化疗医嘱进行分类及统计分析,探讨不合理用药存在的原因,并及时干预。统计分析2018年7—12月对不合理医嘱干预效果评价并总结改善不合理用药的方法及对策。结果2018年抗肿瘤药物不合理医嘱占比0.63%,2018年1—6月与2018年7—12月不合理医嘱占比分别为0.92%,0.37%,差异有统计学意义(P<0.01),排名前4的不合理医嘱即溶媒种类、溶媒量、给药剂量及给药顺序的占比分别为0.26%,0.22%,0.18%,0.11%,采取干预措施后不合理医嘱占比分别降至0.12%,0.07%,0.09%,0.04%,差异有统计学意义(P<0.01或P<0.05)。结论药师参与PIVAS抗肿瘤药物审方工作,提高抗肿瘤药物使用的合理性,提供更准确及有效的药学服务,促进临床抗肿瘤药物的合理应用。
Objective To analyze the irrational medical orders of anti-tumor drugs in pharmacy intravenous admixture services(PIVAS)and to evaluate the effect after the effective intervention,so as to standardize the rational use of clinical anti-tumor drugs.Methods The classification and statistical analysis of unreasonable chemotherapy prescriptions approved by the pharmacists in our hospital from January to June 2018 were analyzed,and the causes of irrational medical orders were explored and promptly intervened.The statistical analysis of data from July to December 2018 was carried out,and the effects of unreasonable medical intervention were evaluated.The methods and countermeasures for reducing irrational medical orders were summarized.Results In 2018,the proportion of irrational anti-tumor drug uses was 0.63%.The proportions of irrational medical orders in January-April 2018 and July-December 2018 were 0.92%and 0.37%,respectively.The difference was statistically significant(P<0.01),and the statistics of the top 4 irrational medical orders as the type of solvent,the amount of solvent,the dose of administration,and the order of administration were 0.26%,0.22%,0.18%,and 0.11%,respectively.The ratios were reduced to 0.12%,0.07%,0.09%,and 0.04%,and the differences were statistically significant(P<0.01 or P<0.05).Conclusion Pharmacists participation in the practice of PIVAS anti-tumor drugs could improve the rational use of anti-tumor drugs,ensure more accurate and effective pharmacy services,and promote the rational application of clinical anti-tumor drugs.
作者
刘秀兰
刘异
裘琳
LIU Xiulan;LIU Yi;QIU Lin(Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《医药导报》
CAS
北大核心
2021年第10期1423-1426,共4页
Herald of Medicine
关键词
抗肿瘤药物
不合理医嘱
合理用药
静脉药物集中调配中心
Anti-tumor drugs
Irrational medical orders
Rational medication
Pharmacy intravenous admixture services
