摘要
目的分析甲状腺乳头状癌(PTC)超声弹性成像特征,探讨弹性评分和应变率比值(SR)与程序性细胞死亡基因4(PDCD4)、表没食子儿茶素没食子酸酯(EGCG)、Xklp2靶蛋白(TPX2)表达的相关性。方法86例甲状腺结节患者根据病理结果分为PTC组49例(49个结节)和良性肿瘤组37例(37个结节),均行超声弹性成像获得弹性评分和SR,比较两组差异;分析PTC患者弹性评分、SR与PDCD4、EGCG、TPX2的相关性。结果PTC组弹性评分、SR均高于良性肿瘤组(均P<0.05)。PTC组PDCD4、EGCG表达均低于良性肿瘤组,TPX2表达高于良性肿瘤组(均P<0.05)。PTC患者弹性评分、SR与PDCD4、EGCG表达均呈负相关,与TPX2表达均呈正相关(均P<0.05)。结论PTC的弹性评分和SR与甲状腺良性肿瘤有显著差异;PTC弹性评分、SR与PDCD4、EGCG、TPX2的表达均相关。
Objective To analyze the characteristics of ultrasound elastography in patients with thyroid papillary carcinoma(PTC),and to explore the correlation of ultrasonic elasticity score,strain rate ratio(SR)and expression of programmed cell death gene 4(PDCD4),epigallocatechin gallate(EGCG)and Xklp2 target protein(TPX2).Methods According to the pathological results,a total of 86 patients with thyroid nodules were divided into PTC group(49 thyroid nodules)and benign tumor group(37 thyroid nodules).The differences in elasticity score and SR between the PTC group and the benign tumor group were compared,and the correlation between the elasticity score,SR and PDCD4,EGCG,TPX2 in patients with PTC were analyzed.Results The elasticity score and SR of the PTC group were significantly higher than those of the benign tumor group(both P<0.05).The expression of PDCD4 and EGCG of the PTC group were significantly lower than those of the benign tumor group(both P<0.05),while the expression of TPX2 was significantly higher than that of the benign tumor group(P<0.05).The elasticity score and SR of PTC patients were negatively correlated with the expression of PDCD4 and EGCG,and positively correlated with the expression of TPX2(all P<0.05).Conclusion The elasticity score and SR of patients with PTC and benign thyroid tumors are significantly different.The elasticity score and SR of patients with PTC are correlated with PDCD4,EGCG and TPX2 expression.
作者
郑辉
陈文丽
蔡昆
张明芬
李飞
ZHENG Hui;CHEN Wenli;CAI Kun;ZHANG Mingfen;LI Fei(Department of Ultrasound,Huaibei Miner General Hospital,Anhui 235000,China)
出处
《临床超声医学杂志》
CSCD
2021年第9期708-710,共3页
Journal of Clinical Ultrasound in Medicine
基金
2016年安徽省卫生和计划生育委员会科研计划项目(2016KQ239)。
