摘要
目的:探讨利拉鲁肽注射液联合二甲双胍治疗2型糖尿病患者的临床效果。方法:选取104例2型糖尿病患者,按照随机数字表法分为两组,每组各52例。对照组采用二甲双胍治疗,观察组采用利拉鲁肽注射液联合二甲双胍治疗。比较两组治疗前后糖化血红蛋白(HbAlc)、胰岛素抵抗指数(HOMA-IR)、血清内皮素(ET)、脂联素变化程度和不良反应。结果:治疗后两组HbAlc、HOMA-IR低于治疗前,且观察组低于对照组(P<0.05);治疗后观察组血清ET水平低于对照组,脂联素水平高于对照组(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论:利拉鲁肽注射液联合二甲双胍可降低内皮素,升高脂联素,改善胰岛功能,保护心血管内皮细胞,是临床治疗2型糖尿病安全有效方案。
Objective: To investigate the clinical effects of liraglutide injection combined with metformin in the treatment of patients with type 2 diabetes. Methods: 104 patients with type 2 diabetes were randomized into 2 groups, each with 52 cases. The control group received the treatment with metformin, while the observation group were treated with the combined metformin with liraglutide injection. Then the glycosylated hemoglobin(HbAlc), homeostasis model assessment of insulin resistance(HOMA-IR), serum endothelin(ET), change in adiponectin, and adverse reactions(ADR)were compared between both group before and after treatment. Results: After treatment, the HbAlc and HOMA-IR in the two groups was lower than that before treatment, and the observation group’s was lower than that of the control group(P< 0.05);the serum ET level of observation group was lower than that of control group, and the adiponectin level was higher than that of control group(P<0.05);and there was no significant difference in ADR between the two groups(P>0.05).
作者
王丹丹
WANG Dandan(Dept,of Endocrinology,the People's Hospital of Zhecheng County,Zhecheng 476200,China)
出处
《华夏医学》
CAS
2021年第4期96-99,共4页
Acta Medicinae Sinica
关键词
二甲双胍
利拉鲁肽注射液
2型糖尿病
糖化血红蛋白
metformin
liraglutide injection
type 2 diabetes mellitus
glycosylated hemoglobin(HbAlc)
