摘要
目的:探讨右美托咪定联合乌司他丁对老年妇科腹腔镜手术患者认知能力、血清NSE及S100β蛋白水平的影响。方法:选取125例老年妇科腹腔镜手术患者作为研究对象,采用随机数字表法分为两组。对照组62例在进行麻醉诱导前15 min给予负荷剂量右美托咪定治疗,观察组63例在对照组基础上增加乌司他丁治疗,观察两组患者血清学检测指标、认知功能、炎症因子水平。结果:观察组蒙特利尔认知评估量表(MoCA)评分和简易智力状态检查量表(MMSE)评分高于对照组(P<0.05);血清神经元特异性烯醇化酶(NSE)、S100β蛋白水平均低于对照组(P<0.05);超敏C反应蛋白水平(CRP)、白细胞介素-6(IL-6)以及高迁移率族蛋白B1(HMGB1)水平低于对照组(P<0.05)。结论:右美托咪定联合乌司他丁对老年妇科腹腔镜手术患者认知功能具有一定保护作用,可有效降低血清学检测指标和炎症因子水平。
Objective: To investigate the effects of dexmedetomidine combined with ulinastatin on the postoperative cognitive ability, serum NSE and S100β protein levels in elderly patients undergoing gynecological laparoscopic surgery. Methods: A total of 125 elderly patients undergoing gynecological laparoscopic surgery were selected as the research subjects and randomized into the control group and observation group. 62 patients in the control group were given loading dose of dexmedetomidine 15 minutes before anesthesia induction, while 63 patients in the observation group were given ulinastatin on the basis of the treatment for the control group. Serological indicators, cognitive function and inflammatory cytokines were compared between the two groups. Results: The scores of Montreal Cognitive Assessment Scale(MOCA)and MMSE in observation group were higher than those in control group(P<0.05);serum neuron-specific enolase(NSE)and S100β protein levels were lower than those in control group(P<0.05);and the levels of hypersensitive C-reactive protein(CRP), interleukin-6(IL-6)and high mobility group protein B1(HMGB1)were lower than those in the control group(P<0.05). Conclusion: The treatment of dexmedetomidine combined with ulinastatin has a certain protective effect on the cognitive function of elderly patients undergoing gynecological laparoscopic surgery, and can effectively reduce the levels of serological indicators and inflammatory factors.
作者
靳菲
刘超
王旭
JIN Fei;LIU Chao;WANG Xu(Dept,of Anesthesiology,the People's Hospital of Hebi,Hebi 458030;Dept,of Anesthesiology and Perioperative Medicine,Henan Provincial People’s Hospital,Zhengzhou 450000,China)
出处
《华夏医学》
CAS
2021年第4期91-95,共5页
Acta Medicinae Sinica
关键词
认知能力
右美托咪定
炎症因子
乌司他丁
cognitive ability
dexmedetomidine
inflammatory factor
ulinastatin
