摘要
目的探讨血清C反应蛋白(CRP)、降钙素原(PCT)、可溶性髓系细胞触发受体-1(sTREM-1)在新生儿早发型败血症诊断中的价值。方法选取2019年5月至2020年10月江西省儿童医院收治的100例患儿作为研究对象,将诊断为早发型败血症的50例患儿纳入观察组,未诊断为早发型败血症的50例患儿纳入对照组,记录2组患儿血清CRP、PCT、sTREM-1水平,分析它们在新生儿早发型败血症中的诊断价值。结果观察组CRP、PCT、sTREM-1水平高于对照组,差异均有统计学意义(P<0.05)。sTREM-1单独检测的灵敏度、特异度、准确率较CRP、PCT高,但差异均无统计学意义(P>0.05);CRP+PCT联合检测诊断早发型败血症的灵敏度、特异度及准确率高于CRP、PCT、sTREM-1单独检测,差异有统计学意义(P<0.05);CRP+PCT检测的灵敏度、特异度及准确率高于sTREM-1+CRP、sTREM-1+PCT检测,但差异无统计学意义(P>0.05)。结论CRP、PCT联合检测可提高新生儿早发型败血症的诊断准确率。
Objective To investigate the value of serum C-reactive protein(CRP),procalcitonin(PCT)and soluble myeloid cell trigger receptor-1(sTREM-1)in the diagnosis of early-onset sepsis in neonates.Methods A total of 100 children admitted to Jiangxi Children′s Hospital from May 2019 to October 2020 were selected as the research objects.50 children diagnosed with early-onset sepsis were included in the observation group,and 50 children who were not diagnosed as early-onset sepsis were included in the control group.The serum levels of CRP,PCT and sTREM-1 were detected in the two groups,and their diagnostic value in neonatal early-onset sepsis was analyzed.Results The levels of CRP,PCT and sTREM-1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The sensitivity,specificity and accuracy of sTREM-1 alone were higher than those of CRP and PCT,but the differences were not statistically significant(P>0.05).The sensitivity,specificity and accuracy of the combined detection of CRP+PCT in the diagnosis of early-onset sepsis were higher than those of CRP,PCT and sTREM-1 alone,and the differences were statistically significant(P<0.05).The sensitivity,specificity and accuracy of CRP+PCT were higher than sTREM-1+CRP and sTREM-1+PCT,but the differences were not statistically significant(P>0.05).Conclusion The combined detection CRP and PCT can improve the diagnostic accuracy of neonatal early-onset sepsis.
作者
万玲玲
曾晓辉
喻云
WAN Lingling;ZENG Xiaohui;YU Yun(Neonatal Intensive Care Unit,Jiangxi Children′s Hospital,Nanchang,Jiangxi 330006,China)
出处
《检验医学与临床》
CAS
2021年第18期2648-2650,2654,共4页
Laboratory Medicine and Clinic
基金
江西省卫生健康委员会科技计划项目(20203659)。
