摘要
目的探讨多索茶碱治疗支气管炎的临床疗效。方法选取永新县中医院2019年1月—2020年6月收治的支气管炎患者76例,按照随机数字表法将所有患者分为对照组与观察组,各38例。2组均予以常规治疗,对照组在常规治疗基础上予以氨茶碱注射液治疗,观察组在常规治疗基础上予以多索茶碱治疗。比较2组治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC],症状缓解时间(咳嗽缓解时间、喘息缓解时间、咳痰缓解时间)、住院时间,治疗前后C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α),并观察2组不良反应发生情况。结果治疗前2组FEV1、FVC、FEV1/FVC比较,差异无统计学意义(P>0.05);治疗后观察组FEV1、FVC、FEV1/FVC高于对照组(P<0.05)。观察组咳嗽缓解时间、喘息缓解时间、咳痰缓解时间、住院时间短于对照组(P<0.05)。治疗前2组CRP、TNF-α比较,差异无统计学意义(P>0.05);治疗后观察组CRP、TNF-α低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论多索茶碱治疗支气管炎的临床疗效确切,可有效改善患者肺功能,降低炎性因子表达,缩短症状缓解时间,且安全性较高。
Objective To evaluate the clinical efficacy of doxofylline in the treatment of bronchitis.Methods A total of 76 cases of patients with bronchitis were selected from January 2019 to June 2020 in Yongxin County Hospital of Traditional Chinese Medicine,they were divided into control group and observation group according to random number table method,with 38 cases in each group.Both groups were given routine treatment,the control group was treated with aminophylline injection on the basis of routine treatment,the observation group was treated with doxofylline on the basis of routine treatment.Lung function indexes(FEV1,FVC,FEV1/FVC) before and after treatment,symptom relief time(cough relief time,wheezing relief time,expectoration relief time),hospitalization time,CRP and TNF-α before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,there was no significant difference in FEV1,FVC and FEV1/FVC between the two groups(P>0.05);after treatment,FEV1,FVC and FEV1/FVC in observation group were higher than those in control group(P<0.05).The cough relieving time,wheezing relieving time,expectoration relieving time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).There was no significant difference in CRP and TNF-α between the two groups before treatment(P>0.05);after treatment,CRP and TNF-α in observation group were lower than those in control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Doxofylline have an exact clinical effect for bronchitis,which can effectively improve the lung function of patients,reduce the expression of inflammatory factors,and shorten the time for relieving symptoms,and with high safety.
作者
贺小美
顾烨
王丹
HE Xiaomei;GU Ye;WANG Dan(Department of Respiratory Medicine,Yongxin County Hospital of Traditional Chinese Medicine,Jif an 343400,China)
出处
《临床合理用药杂志》
2021年第24期38-40,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
支气管炎
多索茶碱
治疗结果
炎性因子
不良反应
Bronchitis
Doxotheophylline
Treatment outcome
Inflammatory factor
Adverse reactions
