摘要
目的:分析艾司西酞普兰联合阿戈美拉汀治疗老年抑郁伴失眠患者的效果。方法:2019年2月-2020年2月收治老年抑郁伴失眠患者70例,随机双盲法分为两组,各35例。对照组采取艾司西酞普兰治疗;研究组采取艾司西酞普兰联合阿戈美拉汀治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组治疗1周、2周、4周、8周后的汉密尔顿抑郁量表(HAMD)评分和匹兹堡睡眠质量指数量表(PSQI)评分均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对老年抑郁伴失眠患者应用艾司西酞普兰联合阿戈美拉汀治疗,可取得很好的疗效,能有效改善抑郁和失眠症状,且不良反应较少。
Objective:To analyze the effect of escitalopram combined with agomelatine in the treatment of elderly patients with depression and insomnia.Methods:From February 2019 to February 2020,70 elderly patients with depression and insomnia were selected,they were randomly divided into the two groups with 35 cases in each group.The control group was treated with escitalopram.The study group was treated with escitalopram combined with agomelatine.We compared the treatment effects of the two groups.Results:The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The HAMD score and PSQI score of the study group after 1 week,2 weeks,4 weeks,and 8 weeks of treatment were lower than those of the control group,the difference was statistically significant(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:Escitalopram combined with agomelatine in the treatment of elderly patients with depression and insomnia can achieve good curative effect,effectively improve the symptoms of depression and insomnia,and has less adverse reactions.
作者
娄元菊
Lou Yuanju(The Third People's Hospital of Jiangmen City,Guangdong Jiangmen 529000)
出处
《中国社区医师》
2021年第26期39-40,共2页
Chinese Community Doctors
