摘要
目的探讨急性缺血性脑卒中(AIS)患者血清神经丝蛋白轻链(FNL)、泛素羧基末端水解酶L1(UCH-L1)水平及其与预后的关系。方法选取2018年6月至2019年12月湖北省宜昌市第二人民医院收治的AIS患者93例作为研究组及同期进行体检的健康志愿者30例作为对照组,比较两组研究对象一般资料,利用酶联免疫吸附试验法(ELISA)检测血清NFL、UCH-L1水平。绘制受试者工作特征曲线(ROC曲线)评价血清NFL、UCH-L1水平对AIS患者预后不良的诊断价值。利用多因素Logistic回归分析影响AIS患者预后不良的危险因素。结果研究组血小板计数水平高于对照组,差异有统计学意义(P<0.05);中度组、重度组患者血清NFL、UCH-L1水平与轻度组比较,差异有统计学意义(P<0.05);AIS患者血清NFL、UCH-L1水平之间呈正相关(r=0.647,P<0.05)。NIHSS评分≥9分、NFL水平>42.03 pg/mL、UCH-L1水平>0.28μg/L是AIS患者预后不良的独立危险因素。结论AIS患者血清NFL、UCH-L1水平与其病情严重程度及预后有关,值得临床推广。
Objective To investigate the expression of serum neurofilament light chain(FNL)and ubiquitin carboxyl-terminal hydrolase L1(UCH-L1)in patients with acute ischemic stroke(AIS)and their relationship with prognosis.Methods A total of 93 patients with AIS in Hubei Yichang Second People′s Hospital from June 2018 to December 2019 were selected as the study group and 30 healthy volunteers were selected as the control group.The general data of the two groups were compared,and the levels of serum NFL and UCH-L1 were detected by enzyme-linked immunosorbent assay(ELISA).The receiver operating characteristic curve(ROC curve)was used to evaluate the diagnostic value of serum NFL and UCH-L1 levels for poor prognosis of AIS patients.Multivariate Logistic regression was used to analyze the risk factors of poor prognosis in AIS patients.Results The level of platelet count in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The levels of SERUM NFL and UCH-L1 in moderate group and severe group were significantly different from those in mild group(P<0.05).There was a positive correlation between NFL and UCH-L1 levels in AIS patients(r=0.647,P<0.05).NIHSS score≥9,NFL level>42.03 pg/mL,UCH-L1 level>0.28μg/L were independent risk factors for poor prognosis in AIS patients.Conclusion The levels of serum NFL and UCH-L1 in patients with AIS are related to their severity and prognosis,which is worthy of clinical promotion.
作者
陈晨晖
程楠
向常清
彭伟
李勇
郑永强
CHEN Chenhui;CHENG Nan;XIANG Changqing;PENG Wei;LI Yong;ZHENG Yongqiang(Department of Emergency Medicine,Second People′s Hospital of Yichang City/Second People′s Hospital of Three Gorges University,Yichang,Hubei 443000,China;Department of Ultrasound,the Fifth People′s Hospital of Yichang City,Yichang,Hubei 443000,China;Department of Neurology,Second People′s Hospital of Yichang City/Second People′s Hospital of Three Gorges University,Yichang,Hubei 443000,China)
出处
《国际检验医学杂志》
CAS
2021年第18期2195-2199,共5页
International Journal of Laboratory Medicine
基金
湖北省卫生健康委员会科研项目(WJ2019M065)。
