摘要
The aim of this study was to reconstruct surface porous structure with hundreds of micrometers and then bio-mineralize Sr-doped Calcium Phosphate(Sr-doped CaP)on Polyetheretherketone(PEEK)profile to enhance its bioactivity.A surface porous structure was prepared on PEEK profile by embedding and acid-etching of SiO2 particles as porogen(SP-PEEK).Then the Sr-doped CaP was further decorated on the porous surface after sulfonation,introduction of Sr-doped CaP crystal seeds and bio-mineralization in 1.5 times simulated body fluid(BSSP-PEEK-CaP/Sr).It was feasible to reconstruct the surface porous structure with hundreds of micrometers on PEEK profile by the present method without damaging its mechanical properties.The Sr-doped CaP crystal seeds effectively promoted the bio-mineralization of bio-inertness PEEK.All as-prepared PEEK did not inhibit the proliferation of cells.ALP of bio-mineralized groups was significantly increased than that of the other groups.The BSSP-PEEK-CaP/Sr obviously affected the morphology and promoted the adhesion and spreading of cells.As a result,the cyto-biocompatibity and bioactivity of PEEK were improved after bio-mineralization.Sr-doped CaP on PEEK most likely was beneficial for cells,which was associated with the increasing of the hydrophilicity on PEEK.This study provided a candidate method to improve the osteogenesis of PEEK implants.
基金
This study is partly supported by the following programs:National Natural Science Foundation of China(Grant No.52035012,51372210)
the Basic Research Foundation Key Project of Sichuan Province(2021JY0046)
Fundamental Research Funds for the Central Universities(2682020ZT91).
