摘要
羊毛是养羊业重要的畜产品和经济来源之一,近年来羊毛蛋白组学研究取得很大进展,羊毛组分和结构的研究为羊毛角蛋白编码基因及其表达调控研究奠定了基础。该文介绍了羊毛的基本结构组成和在羊毛生长发育过程中羊毛相关角蛋白的表达调控机制,角蛋白基因表达具有高度的组织特异性和时空性,这种特异性表达受到严格调控,而启动子是基因表达调控的关键元件。文章进一步对当前羊毛角蛋白基因启动子研究进展进行综述,分析相关转录因子通过与启动子特异性位点结合来调控最终羊毛性状的机制,围绕羊毛结构、相关基因表达特征以及特异性启动子调控机制等方面论述了羊毛生长发育及其蛋白特异性表达的研究进展,为羊毛发育及分子育种研究提供理论参考。
Wool fiber is one of the most important animal products and income sources in sheep farming.With the development of protein isolation and identification technology,great progress has been made in the study of wool proteomics in recent years.The research on the composition and structure of wool has laid a foundation for the study of wool keratin encoding genes and their expression regulation procedures.This paper introduces the basic structure of wool and the regulation mechanism of wool related keratin proteins during the growth and development of wool.Keratin gene expression is highly tissue specific and spatiotemporal,and this specific expression rule is strictly regulated.The promoter is the key element of gene expression regulation.This paper further reviewed the researches on the promoters of wool keratin related genes and analyzed the regulation of the final wool traits through related transcription factors binding to the promoter specific sites.In this article,the current research progress of wool growth and development and the specific expression of wool keratin proteins were reviewed,including the aspects of wool structure,related gene expression characteristics,and specific promoters regulatory mechanisms,so as to provide theoretical reference for wool development and molecular breeding research.
作者
胡馨予
姚逸安
胡情情
俞可心
石国庆
万鹏程
代蓉
管峰
HU Xinyu;YAO Yian;HU Qingqing;YU Kexin;SHI Guoqing;WAN Pengcheng;DAI Rong;GUAN Feng(College of Life Sciences,China Jiliang University,Hangzhou 310018,China;Animal Husbandry and Veterinary Institute,Xinjiang Academy of Agricultural and Reclamation Science,Shihezi 832000,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2021年第8期1705-1713,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31672394)
国家重点研发计划项目(批准号:2017YFD0501904)
国家绒毛用羊产业技术体系(批准号:CARS-40-07)
兵团科技攻关与成果转化计划项目(批准号:2016AC027)
兵团中青年科技创新领军人才专项(批准号:2018CB025)资助的课题。
