摘要
目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者呼吸道多重耐药菌(MDRB)感染的危险因素。方法回顾性分析2015年10月至2019年10月郑州市第三人民医院收治的112例AECOPD患者的临床资料,根据患者MDRB感染情况分为MDRB感染组21例和非MDRB感染组91例。单因素比较两组患者临床资料,对存在显著差异的指标进行多因素logistics回归,分析影响AECOPD患者MDRB感染的危险因素。结果两组患者呼吸衰竭情况、因COPD年住院次数、不良用药史、机械通气时间、抗菌药物使用时间、糖皮质激素使用时间比较差异有统计学意义(P <0.05)。呼吸衰竭、因COPD年住院次数≥3次、不良用药史≥3次、抗菌药物使用时间≥7 d为AECOPD患者MDRB感染的独立危险因素(P <0.05)。结论呼吸衰竭、因COPD年住院次数、不良用药史以及抗菌药物使用时间是AECOPD患者合并MDRB感染的独立危险因素,对此加以预防和控制,有助于降低患者MDRB感染风险。
Objective To investigate the risk factors of respiratory tract multi-drug resistant bacteria( MDRB) infection in patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods The clinical data of 112 patients with AECOPD in Zhengzhou Third People’s Hospital from October 2015 to October 2019 were retrospectively analyzed. According to the MDRB infection,the patients were divided into MDRB infection group( n = 21) and non MDRB infection group( n = 91). The clinical data of the two groups were compared by univariate analysis,and the risk factors of mdrb infection in AECOPD patients were analyzed by multivariate logistic regression. Results There were significant differences between the two groups in terms of respiratory failure,hospitalization times due to COPD,history of adverse drug use,duration of mechanical ventilation,duration of antibiotic use and duration of glucocorticoid use( P < 0. 05). Respiratory failure,hospitalization times due to COPD≥3 times,history of adverse drug use≥3 times and duration of antibiotic use≥7 days were independent risk factors of MDRB infection in AECOPD patients Factors( P < 0. 05). Conclusions Respiratory failure,number of hospitalizations due to COPD,history of adverse drug use and duration of antibiotic use are independent risk factors of MDRB infection in AECOPD patients. Prevention and control of these factors can help to reduce the risk of MDRB infection in AECOPD patients.
作者
李旭东
Li Xudong(Department of Respiratory and Critical Care Medicine,Zhengzhou Third People's Hospital,Zhengzhou 450000,China)
出处
《临床医学》
CAS
2021年第7期25-28,共4页
Clinical Medicine
关键词
慢性阻塞性肺疾病
急性加重期
呼吸道多重耐药菌感染
LOGISTIC分析
Chronic obstructive pulmonary disease
Acute exacerbation
Respiratory tract multi drug resistant bacteria infection
Logistic analysis
