摘要
目的评估颅骨修补术后癫痫发作的预后,探索其相关影响因素。方法回顾性分析2010年1月至2018年12月德州市人民医院71例颅骨缺损修补手术后癫痫发作患者病历资料。结果符合入组条件患者63例,其中,男45例,女18例;年龄20~68岁,平均(44.10±12.66)岁;随访12~106个月,平均51.63个月。5例患者服用抗癫痫药物后出现药物不良反应。7例术后癫痫发作患者死亡。颅骨修补术后(新发与复发)癫痫发作总体预后良好率为39.7%(25/63),其中,新发癫痫发作预后良好率为52.4%(22/42),复发癫痫发作预后良好率为14.3%(3/21),差异有统计学意义(P<0.05)。结论在癫痫发作症状控制方面,相比颅骨修补术后复发癫痫发作患者,新发癫痫发作患者预后较好。
Objective To evaluate the prognosis of epileptic seizures after cranioplasty and explore the related factors.Methods 71 patients with epileptic seizures after cranioplasty at Dezhou People's Hospital from January 2010 to December 2018 were analyzed retrospectively.Results 63 patients were finally included,including 18 females and 45 males.They ranged in age from 20 to 68 years,with a mean age of(44.10±12.66)years.The median follow-up time was 51.63 months,ranging from 12 to 106 months.Adverse drug reactions occurred in 5 patients after taking antiepileptic drugs.7 patients with postoperative epileptic seizures died.The favorable prognosis rate of seizures following cranioplasty was 39.7%(25/63).Among them,the favorable prognosis rate of new-onset seizures was 52.4%(22/42),and that of recurrent seizures was 14.3%(3/21),the difference between them was statistically significant(P<0.05).Conclusion In terms of epilepsy symptom control,compared with patients with recurrent seizures after cranioplasty,patients with new-onset seizures have a better prognosis.
作者
周君
石星原
张庆玲
刘向辉
郭运林
张之营
张建
Zhou Jun;Shi Xingyuan;Zhang Qingling;Liu Xianghui;Guo Yunlin;Zhang Zhiying;Zhang Jian(Department of Neurology,Dezhou People's Hospital,Dezhou 253000,China;Labor Union,Weifang Yidu Central Hospital,Weifang 262500,China;Department of Neurosurgery,Dezhou People's Hospital,Dezhou 253000,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2021年第5期356-359,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
山东省保健科技协会技术课题(SDBJKT20180004)。
关键词
颅骨修补术
癫痫发作
并发症
预后
Cranioplasty
Epileptic seizure
Complication
Prognosis
