摘要
半乳糖凝集素-3(Gal-3)是半乳糖凝集素家族中唯一一种嵌合体结构蛋白,含有一个特定的糖基识别结构域(CRD),能够特异性识别并结合半乳糖,此结构域可介导细胞与细胞之间的黏附和识别,并且能够促进部分肿瘤细胞的增殖和转移等。改良的橘皮果胶(MCP)可通过特异性结合肿瘤相关蛋白Gal-3糖基识别结构域,抑制Gal-3与其相关肿瘤受体的结合,阻断肿瘤细胞之间相关信号的传导,从而表现出较强的抗肿瘤活性。本文综述了MCP在Gal-3介导肿瘤发生发展过程中相关作用的研究进展。
Galectin-3(Gal-3) is the only chimeric structural protein in the galectin family and contains a specific carbohydrate recognition domain(CRD) that specifically recognizes and binds to galactose. The CRD can mediate cell-to-cell adhesion and recognition. It can also promote the proliferation and metastasis of some tumor cells. By specifically binding to the tumor-associated protein of Gal-3’s CRD, modified citrus pectin(MCP) could inhibit the binding of Gal-3 to its associated tumor receptors and block the transduction of relevant signals between tumor cells, which shows strong anti-tumor activities. This paper reviews the research progress in the role of MCP in Gal-3-mediated tumorigenesis and development.
作者
李仪晴
李小玉
白晶晶
李虎
张涛
Li Yiqing;Li Xiaoyu;Bai Jingjing;Li Hu;Zhang Tao(School of Laboratory Medicine,Zunyi Medical University,Zunyi,563000;Department of Laboratory Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi,563006)
出处
《化学通报》
CAS
CSCD
北大核心
2021年第9期895-899,共5页
Chemistry
