摘要
目的探究胰岛素+达格列净治疗2型糖尿病患者对其血糖水平、不良反应发生情况和临床总有效率的影响。方法随机抽取2019年1月—2020年12月于该院接受治疗的50例2型糖尿病患者作为研究对象,对其临床资料进行回顾性分析,根据治疗方案的不同将50例患者分为两组。采用重组甘精胰岛素治疗的23例患者为对照组,另采用胰岛素+达格列净治疗的27例患者为观察组,对两组患者的治疗前后的血糖水平进行统计,并比较两组不良反应发生率和治疗总有效率。结果治疗前,两组的空腹血糖(fasting blood glucose,FPG)、餐后2 h血糖(2 h plasma glucose,2 hPG)、糖化血红蛋白(glycated hemoglobin,HbA1c)水平比较,差异无统计学意义(P>0.05);治疗后,两组FPG、2 hPG、HbA1c均较治疗前有所下降,差异有统计学意义(P<0.05),观察组治疗后各项血糖指标水平均低于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为21.74%,总有效率为73.91%,观察组的不良反应发生率为14.81%,总有效率为96.30%,对照组的不良反应发生率与观察组相比,差异无统计学意义(P>0.05),对照组总有效率低于观察组,差异有统计学意义(P<0.05)。结论采用胰岛素+达格列净治疗2型糖尿病可有效控制患者的高血糖症状,在确保治疗安全性的同时,还可促进治疗效果的提高。
Objective To explore the effect of insulin+dapagliflozin on the blood glucose level,the occurrence of adverse reactions and the total clinical effective rate in patients with type 2 diabetes.Methods Fifty patients with type 2 diabetes who were treated in the hospital from January 2019 to December 2020 were randomly selected as the research objects,and their clinical data were retrospectively analyzed.The 50 patients were divided into two groups according to different treatment plans.23 patients treated with recombinant insulin glargine were the control group,and 27 patients treated with insulin+dapagliflozin were the observation group.The blood glucose levels of the two groups before and after treatment were counted,and the two groups were compared of the incidence of adverse reactions and the total effective rate of treatment.Results Before treatment,there was no statistically significant difference in the levels of fasting blood glucose(FPG),2 h plasma glucose(2 hPG)and glycated hemoglobin(HbA1c)between the two groups(P>0.05);after treatment,the FPG,2 hPG,Hb A1c of the two groups were all lower than before treatment,the difference was statistically significant(P<0.05),and the blood glucose levels of the observation group after treatment were lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 21.74%,and the total effective rate was 73.91%.The incidence of adverse reactions in the observation group was 14.81%and the total effective rate was 96.30%.The incidence of adverse reactions in the control group was not statistically significnat difference compared with the observation group(P>0.05).The total effective rate of the control group was lower than that of the observation group,and the difference was statistically significant(P<0.05).Conclusion The use of insulin+dapagliflozin in the treatment of type 2 diabetes can effectively control the symptoms of hyperglycemia in patients.While ensuring the safety of the treatment,it
作者
邱荣奎
QIU Rongkui(Department of Endocrinology,Xiangshui County Hospital of Traditional Chinese Medicine,Xiangshui,Jiangsu Province,224600 China)
出处
《糖尿病新世界》
2021年第13期52-55,共4页
Diabetes New World Magazine
