摘要
年龄相关性黄斑变性(age-related macular degeneration,AMD)是一种影响视网膜黄斑区功能,引起中心视力进行性损伤的眼科疾病,是导致>60岁老年人视力受损的主要原因。随着中国社会老龄化进程的日益加深,AMD的患病率逐渐升高。AMD的具体发病机制尚不完全明确,构建合适的动物模型有助于阐明其相关病理机制。错综复杂的危险因素共同推动了AMD的发生发展,分析AMD的危险因素对动物模型的构建具有启示作用。
Age-related macular degeneration(AMD)is an ophthalmic disease that affects the function of the macular area of the retina and causes progressive damage to the central vision.It is a leading cause of visual impairment to elderly people aged over 60 years.With the deepening of Chinese society’s aging process,the prevalence of AMD is gradually increasing.The molecular mechanisms underlying the specific pathogenesis of AMD is poorly understood.The construction of a suitable animal model is critical to clarifying the pathogenesis of AMD.Intricate risk factors have jointly promoted the occurrence and development of AMD.Therefore,analysis of AMD risk factors may showed some light on its animal construction.
作者
陈晨凯
王颖异
曹程
许惠琴
朱悦
段金廒
郭建明
CHEN Chenkai;WANG Yingyi;CAO Cheng;XU Huiqin;ZHU Yue;DUAN Jin’ao;GUO Jianming(Nanjing University of Traditional Chinese Medicine,Jiangsu Key Laboratory of High Technology Research of TCM Formulae,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing 210023,China;Nanjing University of Traditional Chinese Medicine,Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing 210023,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2021年第15期1894-1900,共7页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81773983)。
关键词
年龄相关性黄斑变性
危险因素
临床分类
动物模型
age-related macular degeneration
risk factor
clinical classification
animal models
