摘要
阿霉素是一类蒽环类广谱抗肿瘤的抗生素,为临床上一线化疗药物,但该药物在化疗过程中产生具有明显的心脏毒性等不良反应,以及易产生多药耐药性而限制其临床应用。对中药单体药物抗肿瘤活性、增强化疗药物活性、逆转多药耐药和减轻抗肿瘤药物的毒副作用方面进行了大量研究。本文综述中药单体对阿霉素增效减毒的研究概况,为中药单体对阿霉素增效减毒作用研究提供参考。
Adriamycin is a kind of anthracycline antibiotics with a broad-spectrum anti-tumor effect,which is the first-line chemotherapy drug in clinic.However,the use of the drug results in obvious adverse reactions,such as cardiac toxicity and multidrug resistance during chemotherapy,which limit its clinical application.Chinese medicine monomer has been extensively studied on anti-tumor activity,enhancing chemotherapeutic activity,reversing multidrug resistance and reducing side effects of antitumor drugs.This study reviewed the research of Chinese medicine monomer enhancing efficacy and reducing toxicity of Adriamycin,so as to provide reference for study of synergy and attenuation of Adriamycin.
作者
吴杰
叶娟
曾智
李丹
宋伟
刘刚
周本宏
WU Jie;YE Juan;ZENG Zhi;LI Dan;SONG Wei;LIU Gang;ZHOU Benhong(Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China;Department of Pharmacy, Hospital of Huazhong University of Science and Technology, Wuhan 430074, China;Department of Pathology, Renmin Hospital of Wuhan University, Wuchan 430060, China)
出处
《中医药学报》
CAS
2021年第9期111-120,共10页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金资助项目(81803789)
吴阶平医学基金会临床科研专项资助基金(320.6750)。
关键词
阿霉素
增效减毒
中药单体
抗肿瘤作用
毒副作用
心脏毒性
Adriamycin
Synergy and attenuation
Chinese medicine monomer
Anti-tumor effect
Toxic and side effects
Cardic toxicity
