摘要
With a global prevalence of 7.7 million,ischemic stroke(IS)is one of the leading causes of death and disability worldwide.In China,IS alone contributed to 69.6%of stroke events and accounted for 37.1%of the mortality/disability rate[1].IS is a complex disease that is known to be associated with various genetic variants and clinical and lifestyle risk factors[2].Genome-wide association studies(GWAS)provided evidence for the occurrence of more than 160 IS-associated single nucleotide polymorphisms(SNPs).In terms of clinical risk factors,patients with a history of chronic diseases like hypertension,dyslipidemia,and diabetes mellitus,display a higher risk of developing IS.Among the various lifestyle components,leading a sedentary lifestyle,smoking,and having an unhealthy diet are known to be associated with the risk of IS.Thus,integration of various genetic,clinical,and lifestyle variables might prove to be highly beneficial in the prediction and prevention of IS at the individual level[3].
基金
the Program for Zhejia ng Leadi ng Team of Scie nee and Tech no logy Inno vation[gra nt number:No.2011R50021]
Zhejiang Provincial Natural Science Foundation of China[grant number:No.LQ16H260002]
it was also supported by the National Natural Science Foundation of China[grant number:No.81402762].
