摘要
目的探讨盐酸吡格列酮对2型糖尿病患者血管内皮功能的影响。方法选取2019年1月至12月九江学院附属医院内分泌科确诊的80例2型糖尿病患者,按照随机数字表法分为吡格列酮组和安慰剂组,每组各40例。安慰剂组接受安慰剂治疗,吡格列酮组行盐酸吡格列酮治疗。比较两组血糖控制效果、血管内皮功能、外周血清中非对称性二甲基精氨酸(ADMA)和二甲基精氨酸-二甲胺水解酶(DDAH)水平、心理状态评分、体重指数、不良反应发生情况。结果治疗后,吡格列酮组内皮素(ET-1)、ADMA水平低于安慰剂组,差异有统计学意义(P<0.05);治疗后,吡格列酮组的一氧化氮(NO)、血流介导的血管扩张功能(FMD)、DDAH水平高于安慰剂组,差异有统计学意义(P<0.05)。治疗后,吡格列酮组空腹血糖、餐后2 h血糖、糖化血红蛋白、心理状态评分、体重指数低于安慰剂组,差异有统计学意义(P<0.05)。结论盐酸吡格列酮治疗2型糖尿病疗效显著,安全性好,多加推广应用,有助于提高治疗效果,减少不良反应的发生。
Objective To explore the effect of Pioglitazone Hydrochloride on vascular endothelial function in patients with type 2 diabetes.Methods A total of 80 patients diagnosed with type 2 diabetes in the Department of Endocrinology,Affiliated Hospital of Jiujiang University from January to December 2019 were selected as the research objects,and divided into the Pioglitazone group and the placebo group according to the random number table method,with 40 cases in each group.The placebo group received placebo treatment,and the Pioglitazone group received Pioglitazone Hydrochloride treatment.The blood glucose control effect,vascular endothelial function,and the asymmetric dimethylarginine(ADMA)and dimethylarginine-dimethylarginine in the peripheral serum,the level of methylamine hydrolase(DDAH),mental state scores,body mass index,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of endothelin(ET-1)and ADMA in the Pioglitazone group were lower than those in the placebo group,the differences were statistically significant(P<0.05);nitric oxide(NO),blood flow-mediated vasodilation(Flow-mediated dilation,FMD)and DDAH levels in the Pioglitazone group after treatment were higher than those the placebo group,the differences were statistically significant(P<0.05).After treatment,the fasting blood glucose content,two hours postprandial blood glucose content,glycosylated hemoglobin content,mental state scores,and body mass index of the Pioglitazone group were lower than those of the placebo group,the differences were statistically significant(P<0.05).Conclusion Pioglitazone Hydrochloride is effective in the treatment of type 2 diabetes with good safety.More popularization and application can help improve the treatment effect and reduce the occurrence of adverse reactions.
作者
虞建新
周理兰
许仁炜
YU Jian-xin;ZHOU Li-lan;XU Ren-wei(Department of Endocrinology,Affiliated Hospital of Jiujiang University,Jiangxi Province,Jiujiang 332000,China)
出处
《中国当代医药》
CAS
2021年第26期73-76,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20197204)。
