摘要
目的探讨头孢曲松钠联合亚低温治疗儿童化脓性脑膜炎(PM)的效果。方法回顾性分析2016年1月至2021年1月于郑州大学附属郑州中心医院接受头孢曲松钠治疗的20例PM患儿的临床资料,将其纳入对照组,另取同期于郑州大学附属郑州中心医院接受头孢曲松钠联合亚低温治疗的20例PM患儿的临床资料,将其纳入观察组。两组均连续治疗10 d,观察两组临床疗效,记录两组临床症状、体征消失时间,并对比两组治疗前、治疗10 d后脑脊液生化指标[C反应蛋白(CRP)、降钙素原(PCT)、降钙素基因相关肽(CGRP)]水平。结果观察组临床总有效率高于对照组(P>0.05),观察组退热时间、抽搐消失时间、脑膜刺激征消失时间、肢体活动障碍消失时间短于对照组,差异有统计学意义(P<0.05);治疗10 d后,两组CRP、PCT、CGRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论头孢曲松钠联合亚低温治疗儿童PM可降低脑部炎症反应,缩短患儿临床症状、体征消失时间,提高临床疗效。
Objective To investigate the effects of ceftriaxone sodium combined with mild hypothermia in treating children with purulent meningitis(PM).Methods The clinical data of 20 children with PM who received ceftriaxone sodium treatment in Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2016 to January 2021 were retrospectively analyzed,included in the control group,in addition,the clinical data of 20 children with PM who received ceftriaxone sodium and mild hypothermia treatment in Zhengzhou Central Hospital Affiliated to Zhengzhou University during the same period were selected,included in the observation group.Both groups were treated continuously for 10 days,the clinical efficacy of the two groups was observed,the disappearance time of clinical symptoms and signs of the two groups were recorded,the biochemical indexes of cerebrospinal fluid[C-reactive protein(CRP),procalcitonin(PCT),calcitonin gene-related peptide(CGRP)]of the two groups were compared.Results The clinical effective rate of the observation group was higher than that of the control group(P>0.05),the fever abatement time,convulsion disappearance time,meningeal irritation disappearance time and limb movement disorder disappearance time of the observation group were shorter than those of the control group,with statistical significant differences(P<0.05).After 10 days’treatment,the levels of CRP,PCT and CGRP of the two groups were lower than those of before treatment,and the levels of CRP,PCT and CGRP of the observation group were lower than those of the control group,with statistical significant differences(P<0.05).Conclusion Ceftriaxone sodium combined with mild hypothermia in the treatment of children with PM can reduce inflammatory reaction of brain,shorten the disappearance time of clinical symptoms and signs of children and improve the clinical efficacy.
作者
郭慧颖
段晓峰
GUO Huiying;DUAN Xiaofeng(Department of Infection,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China;Department of Pediatrics,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2021年第25期4673-4675,共3页
Henan Medical Research
关键词
化脓性脑膜炎
儿童
头孢曲松钠
亚低温
purulent meningitis
children
ceftriaxone sodium
mild hypothermia
