摘要
目的探讨不同浓度康复新液对慢性溃疡创面修复及白细胞介素-2(IL-2)表达的影响。方法选取江西省人民医院2018年1月至2020年6月收治的慢性溃疡患者40例,按随机数字表法分为5组,每组8例。各组溃疡创面经清创后用一次性密闭负压吸引材料(VSD)覆盖,分别给予0%(生理盐水)、25%、50%、75%和100%5种不同浓度的康复新液冲洗。比较治疗后5组创面肉芽组织HE染色情况、IL-2表达、新生血管数量及创面面积缩小比例。结果各组创面肉芽组织HE染色显示毛细血管密度各不相同,冲洗液浓度越高组,毛细血管密度越高。与0%组比较,25%组、50%组创面IL-2表达、新生毛细血管数量及面积缩小比例增加,但差异无统计学意义(P>0.05);与0%组比较,75%组、100%组创面IL-2表达、新生毛细血管数量及面积缩小比例显著增加,差异有统计学意义(均P<0.05),但2组间差异无统计学意义(P>0.05)。结论随着浓度的增加,康复新液对慢性溃疡创面修复及IL-2表达的影响逐渐增大,以75%以上的浓度影响显著,结合临床效果及经济角度考虑,康复新液冲洗以75%的浓度最佳。
Objective To explore the effects of different concentrations of Kangfuxin solution on wound repair and interleukin-2(IL-2)expression in patients with chronic ulcer.Methods Forty patients with chronic ulcer admitted to Jiangxi People’s Hospital from January 2018 to June 2020 were randomly divided into five groups,with 8 patients in each group.All wounds were covered with disposable vacuum sealing drainage dressing after debridement.Furthermore,the wounds were washed with Kangfuxin solution at concentrations of 0%(normal saline),25%,50%,75%and 100%in the five groups,respectively.HE staining results of granulation tissue,IL-2 expression,number of new capillaries and wound reduction ratio were compared among the five groups.Results HE staining showed that kangfuxin solution increased capillary density in a dose-dependent manner.Compared with 0%group,the expression of IL-2,number of new capillaries and ratio of wound area reduction were increased signifcantly(P<0.05)in 75%and 100%groups,but those were increased in 25%and 50%groups,there were no statistically difference(P>0.05).However,the differences were not significant between 75%group and 100%group(P>0.05).Conclusion Kangfuxin solution can significantly promote wound repair and IL-2 expression in patients with chronic ulcer at concentrations above 75%.From clinical and economical perspectives,the optimum concentration of Kangfuxin solution is 75%.
作者
熊清华
石卫红
胡云刚
李小林
XIONG Qing-hua;SHI Wei-hong;HU Yun-gang;LI Xiao-lin(Department of Plastic and Maxillofacial Surgery of Jiangxi People’s Hospital,Jiangxi Provincial Key Laboratory of Maxillofacial Plastic and Reconstruction,Nanchang 330006,China)
出处
《实用临床医学（江西）》
CAS
2021年第4期20-23,F0004,共5页
Practical Clinical Medicine
