摘要
目的探讨藏药组药联合西医治疗高海拔地区世居者高血压的临床疗效及安全性。方法选择2021年1月至4月西藏昌都市藏医院收治的世居原发性高血压1级和2级患者75例,依照随机数字表分为试验组37例和对照组38例。试验组在常规西医降压药物治疗基础上联合藏药组药治疗,对照组给予常规西医降压药物治疗,两组均给予连续治疗4周。治疗后进行临床疗效评价,比较两组治疗前后的偶测血压、24 h动态血压监测、血脂四项及联合用药。记录并比较两组治疗过程中不良反应的发生情况。结果两组治疗后偶测血压、24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、白天平均收缩压(dSBP)、白天平均舒张压(dDBP)、夜间平均收缩压(nSBP)、夜间平均舒张压(nDBP)、收缩压血压负荷、舒张压血压负荷均较治疗前降低(P<0.05)。试验组治疗后三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)指标均较治疗前改善(P<0.05),对照组未见改善,差异无统计学意义(P>0.05)。治疗后偶测血压、24 h SBP、dSBP、nDBP、nSBP、收缩压血压负荷、舒张压血压负荷、昼夜节律、TG、HDL-C、LDL-C指标,试验组改善优于对照组,差异具有统计学意义(P<0.05);试验组西药合并用药指标好于对照组,经统计学分析,差异具有统计学意义(P<0.05)。两组患者血压疗效评价和不良反应发生率差异均无统计学意义(P>0.05)。结论藏药组药联合西医降压药物和西医降压药物均能有效控制高海拔地区世居者血压,而藏药组药联合西医在改善偶测血压、降低24 h SBP、dSBP、nDBP、nSBP、收缩压血压负荷、舒张压血压负荷,改善昼夜节律,降低TG、LDL-C及提高HDL-C方面作用更强,可减少西医降压药物合并用药。
Objective To investigate the clinical efficacy and safety of Tibetan medicine combined with western medicine in the treatment of hypertension among natives in the high altitude area.Methods A total of 75 native patients with grade 1 and grade 2 primary hypertension who were admitted to Tibetan Hospital of Qamdo,Tibet from January to April 2021 were selected and divided into experimental group(n=37)and control group(n=38)according to random number table.The experimental group was given combined Tibetan medicine on the basis of conventional Western medicine antihypertensive drug therapy,and the control group was given conventional Western medicine antihypertensive drug therapy,both groups were given continuous treatment for 4 weeks.After treatment,the clinical efficacy was evaluated,and the four items of occasional blood pressure,24 h dynamic blood pressure monitoring,blood lipid and the combination of medication were compared between the two groups before and after treatment.The incidence of adverse reactions between the two groups was recorded and compared.Results After treatment,blood pressure,24 h mean systolic blood pressure(24 h SBP)and 24 h mean diastolic blood pressure(24 h DBP)were measured occasionally in both groups,daytime mean systolic blood pressure(dSB)P,daytime mean diastolic blood pressure(dDBP),nighttime mean systolic blood pressure(nSBP),nighttime mean diastolic blood pressure(nDBP),systolic blood pressure load and diastolic blood pressure load in both groups were lower than those before treatment(P<0.05).After treatment,the indexes of triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in the experimental group were improved compared with before treatment(P<0.05),but not in the control group,with no statistical significance(P>0.05).After treatment,the indexes of occasional blood pressure,24 h SBP,dSBP,nDBP,nSBP,systolic blood pressure load,diastolic blood pressure load,circadian rhythm,TG,HDL-C,LDL-C were measured,and the improvement in the e
作者
李杰
赵英强
Li Jie;Zhao Yingqiang
出处
《中国疗养医学》
2021年第11期1121-1126,共6页
Chinese Journal of Convalescent Medicine
基金
国家重点研发计划课题(2019YFC1710005),东部中心城市社区心脑血管疾病中医防控模式研究及示范基地建设。
关键词
高血压
高海拔
世居
治疗
藏医药
Hypertension
High altitude
Natives
Treatment
Tibetan medicine
