摘要
目的分析血清糖类抗原125(CA125)联合人附睾蛋白4(HE4)检测在上皮性卵巢癌病情评估、预后生存预测中的应用。方法2016年5月至2017年5月54例上皮性卵巢癌患者设为观察组,选取同期进行体检的女性健康人员60例设为对照组。比较两组血清CA125、HE4表达情况,分析CA125、HE4水平与上皮性卵巢癌患者临床病理特征的关系,绘制ROC曲线,采用Keplan-meier生存对比预后情况,Logistic回归模型分析影响预后的相关因素。结果CA125及HE4在观察组中的阳性表达率均显著高于对照组(P<0.05);不同年龄、肿瘤浸润深度、病理学分级比较CA125、HE4阳性表达率差异有统计学意义(P<0.05);在FIGO分期中,Ⅲ~Ⅳ期阳性表达率明显高于Ⅰ~Ⅱ期阳性表达率(P<0.05);盆腔淋巴结阳性、腹主动脉旁淋巴结阳性、腹水的上皮性卵巢癌阳性表达率显著高于无淋巴结转移、无腹水者(P<0.05);Keplan-meier分析显示CA125及HE4表达阴性者生存期显著长于表达阳性者(P<0.05);经非条件多因素Logistic回归模型进一步分析结果显示CA125阳性、HE4阳性、FIGO分期为Ⅲ~Ⅳ期、盆腔淋巴结阳性、腹主动脉旁淋巴结阳性、有腹水、浸润深度≥1/2、病理学分级(G3)是影响上皮性卵巢癌患者预后的独立危险因素(P<0.05)。结论CA125、HE4术前阳性表达在上皮性卵巢癌患者中死亡率较高,临床可通过联合检测CA125、HE4水平,提高早期上皮性卵巢癌患者的诊断率,更有利于评估患者病情进展和预后。
Objective To analyze the application of serum carbohydrate antigen 125(CA125)combined with human epididymis protein 4(HE4)in assessing the disease and predicting the prognosis of the survival of patients with epithelial ovarian cancer.Methods The clinical data of 54 patients with epithelial ovarian cancer from May 2016 to May 2017 were retrospectively analyzed.The patients were set as the experiment group.Another 60 healthy women undergoing physical examination during the same period were selected as the control group.The serum CA125 and HE4 expression levels between the two groups were compared.The relationship between CA125 and HE4 levels and the clinicopathological characteristics of patients with epithelial ovarian cancer was analyzed.ROC curve was drawn and Keplan-meier survival analysis was used to compare the prognosis.Logistic regression model was used to explore the relevant factors affecting the prognosis.Results The positive expression rates of CA125 and HE4 in the experiment group were significantly higher than those in the control group(P<0.05).The older the age was,the deeper the depth of tumor invasion was,the higher the pathological grade was,the higher the positive expression rates of CA125 and HE4 were(P<0.05).In FIGO staging,the positive expression rate of patients in stage III to IV was significantly higher than that of patients in stageⅠtoⅡ(P<0.05).The positive expression rate of CA125 and HE4 in patients with positive pelvic lymph nodes,positive para-aortic lymph nodes,and ascites was significantly higher than that of patients without lymph node metastasis and ascites(P<0.05).Keplan-meier analysis showed that the survival time of patients with CA125 and HE4 negative expression was significantly longer than that of patients with positive expression(P<0.05).Further analysis of the unconditional multivariate logistic regression model showed that positive CA125,positive HE4,FIGO stageⅢ-Ⅳ,positive pelvic lymph nodes,positive abdominal para-aortic lymph nodes,ascites,depth of invasion≥1/
作者
毛爱荣
李战飞
袁晓雁
韩玉新
陈静
MAO Ai-rong;LI Zhan-fei;YUAN Xiao-yan;HAN Yu-xin;CHEN Jing(Jiaozuo District Hospital,988 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Jiaozuo 454150,China;Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
出处
《实用医院临床杂志》
2021年第5期78-82,共5页
Practical Journal of Clinical Medicine
基金
河南省医学科技攻关计划省部共建项目(编号:SB201701043)。
