摘要
目的观察培土固本灸治疗化疗相关性癌因性疲乏的临床疗效以及对促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)、皮质醇激素(cortisol,Cor)水平的影响。方法选取2018年1月—2020年11月就诊于安徽中医药大学第二附属医院肿瘤科的中晚期消化道恶性肿瘤癌因性疲乏患者50例,按随机数字表法分成治疗组(25例)和对照组(25例)。2组均予以标准化疗方案进行化疗,在此基础上,治疗组给予培土固本灸治疗,1次/d,1周为1个疗程,连续治疗2个疗程。比较2组患者治疗前后癌因性疲乏程度及生活质量(EORTC-QLQ-C30);比较2组治疗前后ACTH、Cor水平。结果治疗组治疗后轻度疲乏14例,中度疲乏8例,重度疲乏3例;对照组治疗后轻度疲乏2例,中度疲乏14例,重度疲乏9例;2组治疗后疲乏程度比较差异有统计学意义(Z=-3.435,P=0.001)。治疗后2组患者生活质量评分比较,躯体功能、角色功能及情绪功能治疗组改善优于对照组(均P<0.05);认知功能领域、社会功能领域无明显变化(均P>0.05)。治疗后治疗组Cor水平较对照组升高(P<0.05),ACTH水平较对照组降低(P<0.05)。结论采用培土固本灸治疗化疗相关性癌因性疲乏可有效改善患者疲乏症状,提高生活质量评分,提高患者Cor水平,降低ACTH水平,Cor与ACTH水平变化可能与肿瘤治疗相关性的癌因性疲乏程度有一定联系。
Objective To investigate the clinical effect of the Peitu Guben Moxibustion in the chemotherapy-related cancer-related fatigue and its effect on the levels of adrenocorticotropic hormone(ACTH)and cortisol hormone(COR).Methods Total 50 patients with cancer-related fatigue caused by gastrointestinal cancer who were admitted to the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to November 2020 were selected and divided into treatment group(25 cases)and control group(25 cases)according to random number table method.The two groups were treated with standard chemotherapy regimen.On this basis,the treatment group was treated with the Peitu Guben Moxibustion therapy regimen,once a day,once a week as a course of treatment,for two courses of continuous treatment.After the treatment,the change of cancer-related fatigue degree and quality of life(EORTC-QLQ-C30)before and after treatment were compared between two groups.The levels of ACTH and COR were compared between the two groups before and after treatment,and investigated the correlation with cancer-related fatigue.Results After treatment,the mild fatigue,medium fatigue and severe fatigue patients in the treatment group were respectively 14 cases,8 cases and 3 cases;in the control group,the mild fatigue,medium fatigue and severe fatigue patients were respectively 2 cases,14 cases and 9 cases.The difference between the two groups after treatment was statistically significant(Z=-3.435,P=0.001).After treatment,the improvement of physical function,role function and emotional function in the treatment group was better than that in the control group(all P<0.05).There were no significant changes in cognitive function and social function(all P>0.05).After treatment,the COR level of treatment group was higher than that of control group(P<0.05),while the ACTH level of treatment group was lower than that of control group(P<0.05).Conclusion The Peitu Guben Moxibustion in the treatment of chemotherapy-related cancer-related fatigue ca
作者
冷玉玲
吴勇
周先阳
徐珩
郝皖蓉
丁艳琦
曾永蕾
夏克春
LENG Yu-ling;WU Yong;ZHOU Xian-yang;XU heng;HAO Wan-rong;DING Yan-qi;ZENG Yong-lei;XIA Ke-chun(Oncology Department,the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230031,China)
出处
《中华全科医学》
2021年第9期1565-1568,共4页
Chinese Journal of General Practice
基金
安徽省十三五医疗卫生重点专科项目(皖卫教研2017[30号])
安徽省自然基金面上资助项目(1608085MH233)。
关键词
培土固本灸
癌因性疲乏
生活质量
促肾上腺激素
皮质醇
Peitu Guben Moxibustion
Cancer-related fatigue
Quality of life
Adrenocorticotropic hormone
Cortisol
