食管癌液态活检:检测循环游离DNA作为分子标志物是否可行? 被引量：3

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摘要食管癌(esophageal cancer,EC)是常见的癌症之一,组织病理类型分为食管鳞状细胞癌和食管腺癌。因确诊晚,并缺乏有效的治疗手段,EC成为世界范围的公共健康问题之一。与常规的肿瘤活检不同,液态活检因损伤性小,可作为传统活检的补充甚至替代方法。尤其是细胞游离DNA(cell-free DNA,cf DNA),在癌症临床管理中已表现出应用前景。cf DNA已成为非侵入性癌症诊断和监测的有效循环分子标志物。虽然很多研究报道了cf DNA在各种癌症中的临床应用,但对其在EC中的作用尚缺乏了解。因此,我们就这一主题进行了综述,并讨论了其在EC诊断和监测中的优势及局限性。

作者袁祖阳王新峰耿潇李印牟巨伟谭锋维薛奇高树庚赫捷

机构地区国家癌症中心/国家肿瘤临床医学研究中心/北京协和医学院中国医学科学院肿瘤医院胸外科

出处《癌症》 SCIE CAS 2021年第7期279-292,共14页 Chinese Journal of Cancer

关键词公共健康问题癌症诊断食管鳞状细胞癌液态活检食管腺癌损伤性分子标志物食管癌

分类号 R735.1 [医药卫生—肿瘤]

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