摘要
目的分析替格瑞洛对老年急性ST段抬高型心肌梗死(STEMI)患者采用经皮冠脉介入术(PCI)治疗的作用效果。方法选取2018年12月—2019年12月该院收治的76例老年STEMI患者为研究对象,按随机数表法分为两组,各38例。氯吡格雷组患者PCI术后采用氯吡格雷治疗,替格瑞洛组患者PCI术后采用替格瑞洛治疗,比较两组患者术后左心室整体收缩功能、血脂代谢、不良反应,统计治疗安全性。结果替格瑞洛组术后血脂代谢优于氯吡格雷组,左心室整体收缩功能改善程度高于氯吡格雷组,差异有统计学意义(P<0.05)。替格瑞洛组心血管不良事件发生率5.26%,氯吡格雷组发生率21.05%,差异有统计学意义(χ^(2)=4.416,P=0.042)。替格瑞洛组不良反应发生率7.89%,氯吡格雷组发生率13.16%,差异无统计学意义(χ^(2)=0.140,P=0.709)。结论替格瑞洛对老年急性ST段抬高型心肌梗死患者经经皮冠脉介入术治疗,改善患者左心室整体收缩功能明显,调节血脂代谢更佳,安全性高。
Objective To analyze the effect of ticagrelor on percutaneous coronary intervention(PCI)in elderly patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 76 elderly STEMI patients admitted to the hospital from December 2018 to December 2019 were selected as the research objects,and they were divided into two groups according to the random number table method,with 38 cases in each group.Patients in the clopidogrel group were treated with clopidogrel after PCI,and patients in the ticagrelor group were treated with ticagrelor after PCI;the overall left ventricular systolic function,blood lipid metabolism,and adverse reactions were compared between the two groups,and the treatment safety was statistically collected.Results Postoperative blood lipid metabolism in the ticagrelor group was better than that in the clopidogrel group,and the overall left ventricular systolic function was improved more than that in the clopidogrel group,the difference was statistically significant(P<0.05).The incidence of cardiovascular adverse events was 5.26%in the ticagrelor group and 21.05%in the clopidogrel group.The difference was statistically significant(χ^(2)=4.416,P=0.042).The incidence of adverse reactions was 7.89%in the ticagrelor group and 13.16%in the clopidogrel group,the difference was not statistically significant(χ^(2)=0.140,P=0.709).Conclusion The percutaneous coronary intervention for ticagrelor in elderly patients with acute ST-segment elevation myocardial infarction can significantly improve the overall left ventricular systolic function,regulate blood lipid metabolism,and is safer.
作者
王晓霞
WANG Xiaoxia(Department of Cardiology,People's Hospital of Yanggu County,Yanggu,Shandong Province,252300 China)
出处
《系统医学》
2021年第11期15-17,21,共4页
Systems Medicine
关键词
替格瑞洛
急性ST段抬高型心肌梗死
经皮冠脉介入术
血脂代谢
左心室整体收缩功能
Ticagrelor
Acute ST-segment elevation myocardial infarction
Percutaneous coronary intervention
Lipid metabolism
Overall left ventricular systolic function
