摘要
目的研究不同剂量低分子肝素联合泼尼松对肾病综合征患者肾功能和凝血指标的影响。方法选择2018年3月-2020年2月于该院接受治疗的肾病综合征的120例患者,依据随机分组法分为观察组和对照组,观察组按低分子肝素的使用剂量将其分为大剂量组、中剂量组、小剂量组。对照组采用常规治疗方法,观察组在常规治疗的基础上加入不同剂量的低分子肝素进行皮下注射治疗。比较两组患者的临床效果。结果4组患者治疗后对照组患者24 h尿蛋白定量(1.81±0.69)g、血清蛋白(30.95±3.67)g/L、尿素氮(8.82±0.68)mmol/L、肌酐(199.65±13.89)μmol/L的改善效果均低于观察组,其中大剂量组24 h尿蛋白定量(1.14±0.24)g、血清蛋白(36.12±5.03)g/L、尿素氮(7.04±0.41)mml/L、肌酐(126.41±13.83)μmol/L效果更加明显;观察组患者的治疗效果优于对照组,不良反应的发生率低于对照组(20.00%),其中大剂量组效果明显(3.33%);观察组凝血指标优于对照组,大剂量组凝血指标最理想,差异有统计学意义(P<0.05)。结论对肾病综合征的患者使用传统的药物治疗方案加上低分子肝素能够有效改善患者的高血凝状态。
Objective To study the effects of different doses of low molecular weight heparin combined with prednisone on renal function and coagulation indexes in patients with nephrotic syndrome.Methods Selected 120 patients with nephrotic syndrome in the hospital from March 2018 to February 2020.According to the random grouping method,they were divided into observation group and control group.According to the dosage of low molecular heparin,the observation group was divided into high-dose group middle-dose group,low-dose group.The control group adopted conventional treatment methods,and the observation group added different doses of low-molecular-weight heparin to subcutaneous injection treatment on the basis of conventional treatment.Compared the clinical effects of the two groups of patients.Results After treatment of the 4 groups of patients,the 24 h urine protein quantitative(1.81±0.69)g,serum protein(30.95±3.67)g/L,urea nitrogen(8.82±0.68)mmol/L and creatinine(199.65±13.89)μmol/L of the control group were all lower than the observation group.Among them,the effects of 24 h urine protein quantitative(1.14±0.24)g,serum protein(36.12±5.03)g/L,urea nitrogen(7.04±0.41)mmol/L,and creatinine(126.41±13.83)μmol/L in the high-dose group were more obvious;the treatment effect of the observation group was better than the control group,the incidence of adverse reactions was lower than the control group(20.00%),of which the effect of the high-dose group was obvious(3.33%);the coagulation index in the observation group was better than that of the control group,the coagulation index in the high-dose group was the most ideal,the difference was statistically significance(P<0.05).Conclusion The use of traditional drug therapy plus low molecular weight heparin for patients with nephrotic syndrome can effectively improve the patient's hypercoagulable state.
作者
刘芳
赵锦
LIU Fang;ZHAO Jin(Department of Nephrology,Dongda Hospital,Shanxian,Shandong Province,274300 China;Department of Nephrology,Zibo First Hospital,Zibo,Shandong Province,255200 China)
出处
《系统医学》
2021年第11期7-10,共4页
Systems Medicine
关键词
低分子肝素
泼尼松
肾病综合征
肾功能
凝血指标
Low molecular weight heparin
Prednisone
Nephrotic syndrome
Renal function
Coagulation index
