摘要
目的观察对慢性肾脏病患者实施他汀类药物治疗的临床效果和价值。方法选取2018年5月至2019年6月本院收治的80例慢性肾脏病患者,根据平衡序贯法分为对照组(n=38)和观察组(n=42)。对照组采用常规治疗,观察组在对照组基础上联合他汀类药物治疗。比较两组临床疗效、用药安全性、肾功能及肾小球滤过率改善情况。结果观察组治疗总有效率为95.2%,明显高于对照组的78.9%(P<0.05)。观察组不良反应发生率为2.3%,低于对照组的15.7%(P<0.05)。治疗后,观察组Bun、SCr、24 h尿蛋白水平、肾小球滤过率均低于对照组,eGFR明显高于对照组(P<0.05)。结论对在常规治疗方案的基础上联合开展他汀类药物治疗慢性肾脏病患者,在提升临床疗效、治疗安全性及保护肾脏方面具有显著价值。
Objective To observe the clinical effect and value of statin therapy in patients with chronic kidney disease.Methods 80 patients with chronic kidney disease admitted to our hospital from May 2018 to June 2019 were selected and they were divided into control group(n=38)and observation group(n=42)according to the balanced sequential method.The control group was treated with conventional treatment,and the observa-tion group was treated with statins on the basis of the control group.The clinical efficacy,medication safety,renal function and glomerular filtration rate improvement between the two groups were compared. Results The total effective rate of treatment in the observation group was 95.2%, which was significantly higher than 78.9% in the control group (P<0.05). The adverse reaction rate in the observation group was 2.3%, which was lower than 15.7% in the control group (P<0.05). After treatment, the Bun, SCr, 24 h urine protein levels, glomerular filtration rate in the observation group were lower than the control group, and eGFR was significantly higher than the control group (P<0.05). Conclusion To carry out drug treatment for patients with chronic kidney disease, it is recommended to jointly carry out statin therapy on the basis of conventional treatment plan, it has significant value in improving clinical efficacy, treatment safety and protecting the kidney.
作者
王楠
闻俊
WANG Nan;WEN Jun(Department of Nephrology,Liaoyou Baoshihua Hospital,Panjin,Liaoning,124000,China)
出处
《当代医学》
2021年第26期25-27,共3页
Contemporary Medicine
关键词
慢性肾脏病
他汀类药物
治疗效果
肾脏保护
Chronic kidney disease
Statins
Therapeutic effect
Renal protection
