摘要
目的探索直接抗球蛋白试验(DAT)阳性溶血性贫血(HA)与性别、年龄及ABO血清学指标(抗-A、抗B、抗-AB、抗-D;Ac、Bc、Oc)相关性,为临床明确诊断提供帮助。方法1)将西安交通大学第二附属医院近年来做过DAT试验HA患者2832例按结果分为阳性观察组382例,阴性对照组2450例。2)运用SPSS 25.0统计学软件分析观察组与性别、年龄及ABO血清学指标相关性。结果DAT阳性HA发病风险:女性明显比男性高(OR=1.712,CI95%=[1.365,2.147];P<0.01),且不同年龄段男女间存在差异;ABO血清学指标抗-A阳性或Ac阴性时明显升高(OR=1.429,CI95%=[1.150,1.775],P<0.01),Oc阳性时明显升高(OR=21.369,CI95%=[13.813,33.057],P<0.01)。31~40岁男性明显易发混合型(OR=19.304,CI95%=[2.208,168.751],P<0.01),41~50岁女性明显易发冷抗体型(OR=3.981,CI95%=[1.545,10.259];P<0.01);ABO血清学指标抗-AB阳性易发混合型(OR=1.852,CI95%=[1.027,3.339],P<0.05),Oc阳性明显易发温抗体型(OR=4.018,CI95%=[1.386,1.646],P<0.01)。结论DAT阳性HA与性别显著相关;与年龄(显著)相关;与ABO血清学指标抗-A、Oc阳性,Ac阴性显著正相关。
Objective To explore the correlation of DAT-positive hemolytic anemia(HA)with gender,age,and ABO serological indicators(anti-A,anti-B,anti-AB,anti-D;Ac,Bc,Oc),so as to provide references for clinical diagnosis.Methods 2832 HA patients who had underwent DAT tests in the Second Affiliated Hospital of Xi′an Jiaotong University in recent years were divided into the positive-DAT patients(n=382)and negative-DAT patients(n=2450)according to the testing results.The correlation between the positive-DAT patients and the sex,age and ABO serological indicators was analyzed using SPSS 25.0 statistical software.Results DAT-positive HA risk in women were significantly higher than men(OR=1.712,CI95%=[1.365,2.147],P<0.01),and it differed significantly by ages;it increased significantly with the presence of positive anti-A,negative Ac(OR=1.429,CI95%=[1.150,1.775];P<0.01),and positive Oc(OR=21.369,CI95%=[13.813,33.057];P<0.01).Men aged 31~40 were prone to develop mixed type(OR=19.304,CI95%=[2.208,168.751];P<0.01),women aged 41~50 were prone to cold antibody(OR=3.981,CI95%=[1.545,10.259];P<0.01);anti-AB positive patients were prone to mixed type(OR=1.852,CI95%=[1.027,3.339];P<0.05),Oc positive was prone to warm antibody(OR=4.018,CI95%=[1.386,1.646],P<0.01).Conclusion DAT-positive HA is significantly correlated with gender and age,and is positively correlated with anti-A,Oc positive and Ac negative.
作者
权军辉
邵香
张明刚
QUAN Junhui;SHAO Xiang;ZHANG Minggang(Department of Blood Transfusion,Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,China;Spleen and Stomach First Ward,Shaanxi Provincial Hospital of Traditional Chinese Medicine)
出处
《中国输血杂志》
CAS
2021年第8期847-850,共4页
Chinese Journal of Blood Transfusion
