摘要
目的探讨新疆柯尔克孜族成人非酒精性脂肪性肝病(NAFLD)的患病率及临床特征。方法选取2018年新疆维吾尔自治区阿合奇县地区常住柯尔克孜族成人全民体检数据,共19843例,分析NAFLD患病率。经腹部B超确诊NAFLD的1396例为病例组,按1∶3的比例选取年龄、性别、地区相匹配的4188例非NAFLD者为对照组;分析NAFLD患者临床特征及其危险因素。结果柯尔克孜族成人NAFLD总体、男性、女性患病率分别为7.0%、7.8%、6.2%(标化后分别为6.8%、7.5%、6.0%),男性患病率高于女性(P<0.01)。肥胖、糖尿病及高血压组的NAFLD患病率明显升高,分别为19.0%、20.6%、18.5%。NAFLD组的BMI、腰围、甘油三酯、AST、ALT均高于对照组(均P<0.01)。NAFLD人群中有17.2%合并一种代谢紊乱疾病,62.0%合并两种代谢紊乱。Logistics回归分析显示:腰围(OR=4.08,95%CI:3.04~5.10)、空腹血糖(OR=3.76,95%CI:2.86~4.93)、BMI(OR=3.32,95%CI:2.16~4.38)是NAFLD发生的主要危险因素;而文化程度(OR=0.42,95%CI:0.24~0.69)、运动(OR=0.68,95%CI:0.45~0.96)是保护因素。结论柯尔克孜族成人NAFLD患病率低于全国水平,NAFLD患者常合并多种代谢紊乱。腰围、空腹血糖、BMI是其患NAFLD的主要危险因素,而文化程度、运动为保护因素。
Objective To explore the prevalence and characteristic of Non-alcoholic fatty liver disease(NAFLD)among the ethnic Kirghiz adult in Xinjiang Province.Methods The study was conducted based on the national health checkup in Xinjiang province during 2018.A total of 19843 participants of Kirghiz adults in Aheqi County),Xinjiang Uygor Autonomous Region were selected for physical examination),questionnaires),blood biochemical indicators detection(FBG),TG),LDL-C),HDL-C),TC),ALT and AST)and abdominal ultrasonography.A total of 1396 patients diagnosed with NAFLD by abdominal ultrasonography were selected as the case group),and 4188 non-NAFLD subjects matched in age),sex and region were selected as the control group at a ratio of 1:3.The clinical characters and risk factors of NAFLD patients were analyzed.Results The overall prevalence of NALFD in Kirghiz adults was 7.0%),7.8%in male),and 6.2%in female(standardized to 6.8%),7.5%),and 6.0%),respectively).The prevalence in male was higher than that in female(P<0.01).The prevalence of NAFLD in the obesity),diabetes),and hypertension group was significantly increased),which was 19.0%),20.6%and 18.5%),respectively.Body mass index(BMI)),waist circumference(WC)),triglycerides),AST(aspartate aminotransferase)and ALT(alanine transamilase)in the NAFLD group were all higher than those in the control group(all P<0.01).In the NAFLD group),17.2%had another one metabolic disorder and 62.0%had another two metabolic disorders.Logistic regression analysis showed that waist circumference(OR=4.08),95%CI:3.04~5.10)),FBG(OR=3.76),95%CI:2.86~4.93)and BMI(OR=3.32),95%CI:2.16~4.38)were the main independent risk factors for NAFLD.Literacy(OR=0.42),95%CI:0.24~0.69)and physical activity(OR=0.68),95%CI:0.45~0.96)were protective factors.Conclusion The prevalence of NAFLD in Kirgiz adults in Xinjiang is lower than the national average.More than half of NAFLD patients are comorbidity with at least two metabolic abnormalities.WC),FBG and BMI were the independent risk factors for NAFLD),however),literacy a
作者
诸葛瑾慧
苏银霞
张明琛
姚华
ZHUGE Jinhui;SUN Yinxia;ZHANG Mingchen;YAO Hua(School of Public Health,Xinjiang Medical University,Urumqi 830011,China;School of Health Management,Xinjiang Medical University,Urumqi 830011,China;Department of Endocrinology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)
出处
《公共卫生与预防医学》
2021年第5期33-37,共5页
Journal of Public Health and Preventive Medicine
基金
国家自然科学基金项目(81760161)。
