摘要
目的分析妊娠合并甲状腺肿的孕妇群体其机体甲状腺激素水平的变化情况,并对疾病同妊娠结局的关系进行分析,以指导临床合理干预。方法纳入2020年1月-2021年2月收治的55例甲状腺肿合并妊娠女性为实验组,按孕周不同分成早期组(n=17)、中期组(n=20)与晚期组(n=18),并选择同期体检的55名健康妊娠女性为对照组,采集各研究对象血清检测各甲状腺激素(FT3、FT4、TSH、TPOAb)水平,且均随访至分娩时刻,比较各组妊娠结局。结果同对照组比较,实验组不同亚组FT3、FT4、TSH水平更低,TPOAb水平更高,实验组随着孕周的增加FT3、FT4、TSH逐渐降低,TPOAb逐渐升高,组间两两比较差异有统计学意义(P<0.05);随访至分娩结束,实验组在孕妇与胎儿各种不良妊娠结局的发生率上均高于对照组(P<0.05)。结论对于甲状腺肿合并妊娠女性,机体甲状腺激素水平会发生变化,且疾病同妊娠不良结局有很大关系。
Objective To analyze the changes of thyroid hormone levels in pregnant women with goiter during pregnancy,and to analyze the relationship between disease and pregnancy outcome,so as to guide rational clinical intervention.Methods A total of 55 cases of pregnant women with goiter and treated from January 2020 to February 2021 were included as experimental group,and they were divided into early stage group(n=17),middle stage group(n=20)and late stage group(n=18).55 healthy pregnant women who underwent physical examination during the same period were selected as control group.Serum of all subjects were collected to detect the levels of thyroid hormones(FT3,FT4,TSH and TPOAb),and all subjects were followed up to the time of delivery to compare the pregnancy outcomes of each group.Results Compared with the control group,the levels of FT3,FT4 and TSH were lower in different subgroups of the experimental group,while the levels of TPOAb were higher.With the increase of gestational age,FT3,FT4 and TSH gradually decreased in the experimental group,while TPOAb gradually increased,and the difference between groups was statistically significant(P<0.05).All patients were followed up to the moment of delivery,which showed that the incidence of all kinds of adverse pregnancy outcomes in pregnant women and fetuses in the experimental group was significantly higher than that in the control group(P<0.05).Conclusion For pregnant women with goiter,thyroid hormone levels will change,and the disease is closely related to the adverse pregnancy outcome.
作者
陈玉环
刘丽华
林丽莉
古岭梅
肖钧
CHEN Yuhuan;LIU Lihua;LIN Lili;GU Lingmei;XIAO Jun(Department of General Medicine,People's Hospital of Zhongkai High-tech Zone,Huizhou 516229,Guangdong,China)
出处
《右江医学》
2021年第8期609-612,共4页
Chinese Youjiang Medical Journal
