摘要
急性肾损伤(acute kidney injury,AKI)是儿童重症监护病房(PICU)的常见危重症,而脓毒症是AKI发生发展的至关重要因素。脓毒症急性肾损伤(sepsis-associated acute kidney injury,SA-AKI)患者往往起病急骤且预后不良,由于目前尚缺乏有力的诊断工具,导致临床上对SA-AKI的干预往往具有滞后性,因此对SA-AKI风险的认识和损伤严重程度的早期识别,以及适时开始支持性治疗,仍然是目前研究的主要内容。目前已有数百种新型生物学标记物及诊断工具出现,用于AKI的早期识别及预后判断。本研究就SA-AKI相关生物学标记物及诊断分层工具的研究进展进行介绍,旨在提高临床医生对SA-AKI的认识。
Acute kidney injury(AKI)is a very common critical disease worldwide,especially in pediatric intensive care unit(PICU).There are many pathogenic factors for AKI,among which sepsis is essential to the development of AKI.Sepsis-associated acute kidney injury(SA-AKI)often have sudden onset and poor prognosis.Because there is still a lack of powerful diagnostic tools,resulting in clinical intervention in SA-AKI often lags behind.Therefore,awareness of SA-AKI risk and early identification of injury severity,as well as timely initiation of supportive treatment,remain the main contents of current research.There are hundreds of new biological markers and diagnostic tools for early identification and prognosis of AKI.This review introduced the progress on diagnosis of SA-AKI.The aim is to improve clinicians′understanding of SA-AKI.
作者
黄佩钰
郑晖
肖政辉
Huang Peiyu;Zheng Hui;Xiao Zhenghui(Hunan Children′s Hospital,Changsha 410007,China;Faculty of Pediatrics,University of South China,Changsha 410007,China)
出处
《中国小儿急救医学》
CAS
2021年第8期712-715,共4页
Chinese Pediatric Emergency Medicine
基金
儿童急救医学湖南省重点实验室(2018TP1028)。
