摘要
中药炭药及中药提取物经高温炭化会产生"中药炭质药物纳米粒",其过程与碳量子点(carbon quantum dots,CDs)的制备工艺类似。由于粒径小于10 nm,称之为"中药衍生碳量子点"。炭药的质量标准是"存性",以中药为原材料制备而成的CDs,不仅具有止血、抗肿瘤等功效,而且具有低毒、水溶性好、生物相容性高、光致发光性能优异等特点,可用于离子检测、药物分析传感、细胞成像、药物递送等领域。从中药衍生碳点在疾病治疗、生物传感和细胞成像等方面的最新进展进行了综述,并对其当前面临挑战和未来发展方向提出建议。
Traditional Chinese medicine(TCM)charcoal drugs and TCM extracts at high temperature will produce"Chinese medicine charcoal drug nanoparticles",which is similar to the preparation process of carbon dots.Since the particle size is less than 10 nm,it is called"carbon quantum dots derived from traditional Chinese medicine".The quality standard of carbon medicine is"storage".Carbon quantum dots prepared from traditional Chinese medicine as raw materials not only have hemostasis and anti-tumor effects,but also have the characteristics of low toxicity,good water solubility,high biocompatibility and excellent photoluminescence performance,which can be used in ion detection,drug analysis sensing,cell imaging,drug delivery and other fields.This paper reviewed the recent advances in the treatment of diseases,biosensors and cell imaging of carbon dots derived from traditional Chinese medicine,and provided some insights into the current challenges and future directions.
作者
黄倩倩
吴成圆
滕云峰
杨一凡
梁玉杰
杨尚青
王中
彭代银
王雷
陈卫东
HUANG Qian-qian;WU Cheng-yuan;TENG Yun-feng;YANG Yi-fan;LIANG Yu-jie;YANG Shang-qing;WANG Zhong-min;PENG Dai-yin;WANG Lei;CHEN Wei-dong(School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Key Laboratory of Chinese Medicinal Formula,Hefei 230012,China;Anhui Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology,Hefei 230012,China;Institute of Pharmaceutics,Anhui Academy of Chinese Medicine,Hefei 230012,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第16期5089-5097,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(81773988)
国家重点研发计划项目(2017YFC1701600)
安徽中医药大学校级科研项目(2018zrzd04)
安徽省自然科学基金项目(1908085QH351)
安徽省科技重大专项项目(18030801131)
安徽省中央引导地方科技发展专项(201907d07050002)
安徽高校协同创新项目(GXXT-2019-043)。
关键词
中药衍生碳点
荧光特性
疾病治疗
生物传感
细胞成像
药物递送
carbon dots derived from traditional Chinese medicine
fluorescence characteristic
disease treatment
biosensors
cell imaging
drug delivery
