摘要
心血管疾病是一种严重威胁人类健康的常见病,具有高患病率和高死亡率的特点,全世界每年死于心血管疾病的人数居各种死因首位。免疫调控等因素与心血管疾病的发生和发展密切相关。Toll样受体(TLRs)是一类模式识别受体,主要表达于细胞膜上,且与微生物识别有关。TLRs能识别特定类型微生物相对保守的分子成分,即病原体相关分子模式,通过激活细胞信号传导途径介导天然免疫反应,还可诱导免疫细胞产生细胞因子,帮助机体建立获得性免疫。近年来研究发现TLRs在心血管疾病中发挥重要作用,现对TLRs与临床心血管疾病的关系进行综述,以期为临床干预提供新思路。
Cardiovascular disease is a common disease that seriously threatens human health.It has the characteristics of high morbidity and high mortality.The number of people who die from cardiovascular disease every year in the world ranks first among all causes of death.Immune regulation and other factors are closely related to the occurrence and development of cardiovascular diseases.Toll-like receptors(TLRs)are a class of pattern recognition receptors,which are mainly expressed on cell membranes and related to microbial recognition.TLRs can recognize the relatively conservative molecular components of specific types of microorganisms,which called pathogen-associated molecular patterns.TLRS can not only activate the natural immune response mediated by cell signal transduction pathway,but also provide molecules and cytokines that induce T cell differentiation,thus helping the body to establish acquired immunity.Recent studies have found that TLRs plays an important role in cardiovascular diseases.This review provides theoretical basis for the relationship between TLRs and some clinical cardiovascular diseases,with a view to providing new ideas for clinical intervention.
作者
邢云
邓伟
唐其柱
XING Yun;DENG Wei;TANG Qizhu(Department of Cardiology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Metabolic and Chronic Diseases,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2021年第8期711-715,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(重点项目)(81530012)
国家重点研发计划资助项目(2018YFC1311300)
国家卫生计生委医药卫生科技发展研究中心资助项目(2016ZX-008-01)
中央高校基本科研业务费专项资金(2042018kf1032)
武汉市科技计划项目(2018061005132295)。
关键词
天然免疫
TOLL样受体
炎性因子
心血管疾病
Innate immunity
Toll-like receptor
Inflammatory factor
Cardiovascular disease
