摘要
以二棕榈酰磷脂酰胆碱(DPPC)和胆固醇为膜材,采用乙醚注入法制备迷迭香精油温敏脂质体,将温敏脂质体添加到壳聚糖-普鲁兰多糖溶液中,以双向拉伸聚丙烯(BOPP)为基膜制备抗氧化复合膜。对迷迭香精油温敏脂质体进行了包封率、粒径分布、多分散性指数(PDI)、相变温度和原子力显微镜的测定,测试了薄膜中精油释放率,验证薄膜温度响应特性。结果表明,制备的温敏脂质体平均包封率为65.6%,平均粒径为164.8nm,PDI平均值为0.163,相变温度为38.5和41.8℃。抗氧化复合膜中精油在42℃下7 d内释放率为94.1%,具有显著的温度响应控制释放作用。
Rosemary essential oil temperature-sensitive liposomes was prepared by ether injection method using dipalmitoylphosphatidylcholine(DPPC)and cholesterol as film materials.Then,antioxidant composite film was obtained by adding the temperature-sensitive liposomes into chitosan-pullulan solution using biaxially oriented polypropylene(BOPP)as base film.The encapsulation efficiency,particle size distribution,polydispersity index(PDI),phase transition temperature and atomic force microscopy of rosemary essential oil temperature-sensitive liposomes were measured.The release rate of essential oil in the antioxidant composite film was tested to verify the temperature response characteristics of the film.The results showed that the average encapsulation efficiency of the prepared temperature-sensitive liposomes was 65.6%,the average particle size was 164.8 nm,the average polydispersity index(PDI)was 0.163,and the switching temperature was 38.5 and 41.8℃.The antioxidant composite film showed a release rate of essential oil at 42℃ within 7 d was 94.1%,indicating that it had a significant temperature-responsive release control effect.
作者
孙君颖
卢莉璟
卢立新
林自东
SUN Junying;LU Lijing;LU Lixin;LIN Zidong(School of Mechanical Engineering,Jiangnan University,Wuxi 214122,Jiangsu,China;Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology,Wuxi 214122,Jiangsu,China;Shandong Bihai Packaging Materials Co.,Ltd.,Linyi 276600,Shandong,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2021年第8期1564-1569,1612,共7页
Fine Chemicals
基金
国家重点研发计划资助项目(2016YFD0400701)。
关键词
温敏脂质体
温度敏感
普鲁兰多糖
壳聚糖
抗氧化
功能材料
temperature-sensitive liposomes
temperature-sensitivity
pullulan
chitosan
antoxidation
functional materials
